Biliary and urinary excretion of sulfated, glucuronidated and tetrahydroxylated bile acids in cirrhotic patients

Adolf Stiehl, Richard Raedsch, Gerda Rudolph, Ursula Gundert‐Remy, Martin Senn – 1 May 1985 – In patients with hepatobiliary diseases, considerable amounts of sulfated and glucuronidated bile acids are excreted in urine. Information on the biliary excretion of these compounds is lacking. We used an intestinal perfusion method to determine the biliary excretion of sulfated and glucuronidated bile acids in eight patients with alcoholic cirrhosis and moderately severe cholestasis and compared results with urinary excretion rates.

Portal pressure, presence of gastroesophageal varices and variceal bleeding

Guadalupe Garcia‐Tsao, Roberto J. Groszmann, Rosemarie L. Fisher, Harold O. Conn, Colin E. Atterbury, Morton Glickman – 1 May 1985 – This study was performed to examine the relationships between portal pressure measurements and the presence of esophagogastric varices, the size of varices and the occurrence of hemorrhage from varices in 93 patients with alcoholic cirrhosis, using standardized measurements of portal pressure by hepatic vein catheterization.

Cefotaxime is more effective than is ampicillin‐tobramycin in cirrhotics with severe infections

Josefina Felisart, Antoni Rimola, Vicente Arroyo, Rosa M. Perez‐Ayuso, Enrique Quintero, Pere Gines, Joan Rodes – 1 May 1985 – We compared the effectiveness and incidence of nephrotoxicity of ampicillin‐tobramycin and cefotaxime in 73 cirrhotics who had severe bacterial infection. Most of these patients had spontaneous peritonitis and/or bacteremia. Patients were randomly allocated into two groups. Group I included 36 patients treated with ampicillin‐tobramycin and Group II comprised 37 patients treated with cefotaxime.

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