Kelvin R. Palmer, William J. Jenkins – 1 March 1985 – Hepatic aldehyde dehydrogenase activity is depressed in alcoholic liver disease and may account for the observation that alcoholics develop high blood acetaldehyde concentrations following ethanol. To determine whether this is a specific defect in alcoholics, aldehyde dehydrogenase was studied in liver tissue obtained from three groups of subjects.
Hans K. Kley, Wolfgang Stremmel, Claus Niederau, Rainer Hehrmann, Omar Shams, Georg Strohmeyer, Hans L. Krüskemper – 1 March 1985 – Gonadal function in idiopathic hemochromatosis (IHC) was evaluated by comparing clinical features and levels of sex hormones in 10 male patients with IHC (cirrhosis, 4; fibrosis, 6), 6 male patients with alcoholic cirrhosis (AC) and 10 healthy, age‐matched controls. Impotence was present in 9 IHC and all AC patients and was associated with decreased plasma testosterone levels.
David L. Williams, Edward R. Sherwood, Rose B. McNamee, Ernest L. Jones, Nicholas R. Di Luzio – 1 March 1985 – Glucan, a particulate β‐1,3‐polyglucose immunomodulator, was evaluated for its ability to modify hepatic metastases and survival in mice with reticulum cell sarcoma. Sarcoma M5076 cells were injected subcutaneously (1 × 105 cells) into syngeneic C57BL/6J male mice. On Day 20, histopathological studies indicated the presence of hepatic micrometastases. At this time, glucan (0.45 mg per mouse) or dextrose was administered intravenously.
Stephen Holt, John Tulip, Douglas Hamilton, Judith Cummins, Anthony Fields, Catherine Dick – 1 March 1985 – The tumoricidal effect of the activation of hematoporphyrin derivative (HpD), by an argon‐ion‐dye‐laser (wavelength 630 nm), was investigated in the Buffalo rat bearing subcutaneous implants of the Morris 7777 hepatoma. Tumor growth was monitored by measuring the tumor volume with constant force callipers. In control animals and those that were pretreated with HpD alone (10 or 20 mg per kg by i.p.
S. A. Jenkins, J. N. Baxter, W. Corbett, P. Devitt, J. Ware, R. Shields, D. Kravetz, J. Terés, J. Bosch, J. Bruix, J. Rodés – 1 March 1985
A. D'arienzo, D. Mattera, G. Ambrogio, L. Duranti, L. Zeuli, G. Mazzacca, Richard Fuller, Charles L. Hoppel – 1 March 1985
William S. Robinson, Gabriel Garcia – 1 March 1985
Robin M. Walker, William J. Racz, T. Francis McElligott – 1 March 1985 – Acetaminophen‐induced (750 mg per kg p.o.) hepatotoxicity in mice is characterized by hepatomegaly and massive centrilobular congestion which precede the appearance of necrosis. The vascular changes are correlated with the morphologic features using liver hemoglobin content to quantitate erythrocyte sequestration, and hematocrit measurements and 125I‐albumin injections to determine plasma and blood volume.
Sandro Vento, John E. Hegarty, Alfredo Alberti, Charles J. O'brien, Graeme J. M. Alexander, Adrian L. W. F. Eddleston, Roger Williams – 1 March 1985 – Using a newly developed indirect T lymphocyte migration inhibition test, cell‐mediated immunity to HBsAg and HBcAg was directly and simultaneously examined in a total of 21 patients with HBsAg‐positive chronic liver disease (CLD), and in seven subjects whose sera contained anti‐HBs (2 previous acute hepatitis B; 4 hepatitis B vaccine recipients and 1 chronic active hepatitis).
Ira M. Jacobson, Jules L. Dienstag, Barbara G. Werner, Doreen B. Brettler, Peter H. Levine, Isa K. Mushahwar – 1 March 1985 – We tested sera collected between 1976 and 1984 from 362 persons in a variety of epidemiologic categories with acute and chronic hepatitis B and from 76 hemophiliacs and drug addicts with hepatitis B antibodies for hepatitis D markers.