Transmission of ground squirrel hepatitis virus to homologous and heterologous hosts

Daniel Trueba, Michael Phelan, John Nelson, Fred Beck, Brian S. Pecha, R. James Brown, Harold E. Varmus, Don Ganem – 1 May 1985 – The infectivity and host range of ground squirrel hepatitis virus (GSHV) have been further examined by animal inoculation experiments. Although carrier squirrel sera usually harbor 109 to 1010 virions per ml as determined by physical measurements, titration of one such serum revealed that squirrel infectivity was lost following dilution of the sample over 106‐fold. Infectivity is markedly reduced by NP40 pretreatment of infected serum.

Sinusoidal caliber in alcoholic and nonalcoholic liver disease: Diagnostic and pathogenic implications

Eva I. Vidins, Robert S. Britton, Alan Medline, Laurence M. Blendis, Yedy Israel, Hector Orrego – 1 May 1985 – Portal hypertension in alcoholic liver disease has been attributed to an increased resistance to blood flow either of sinusoidal or of postsinusoidal origin. The former should be accompanied by sinusoidal compression while the latter is expected to result in an increased or a normal sinusoidal diameter.

Immunologic analysis of mononuclear cells in liver tissues and blood of patients with primary sclerosing cholangitis

Theresa L. Whiteside, Steven Lasky, Lusheng Si, David H. van Thiel – 1 May 1985 – Using monoclonal antibodies to surface antigens, we typed and quantitated the mononuclear cells (MNCs) infiltrating liver tissues from 23 patients with primary sclerosing cholangitis. The circulating T lymphocytes were also enumerated by flow cytometry in 12 of these patients. In blood, T lymphocytes and especially T8+ cells were decreasd. T cells were the major components of MNCs (78%) in portal tracts. Few of these cells were Tac+ or HLA‐DR+. Total MNCs (929 ± 90 vs.

Plasma clearance of intravenously injected aspartate aminotransferase isozymes: Evidence for preferential uptake by sinusoidal liver cells

Yukio Kamimoto, Seikoh Horiuchi, Sumio Tanase, Yoshimasa Morino – 1 May 1985 – Both cytosolic (c‐AAT) and mitochondrial (m‐AAT) isozymes of aspartate aminotransferase (EC 2.6.1.1) appear in serum in some diseases including hepatobiliary dysfunction. The present study aimed at elucidation of the mechanism by which AAT isozymes are cleared from blood. Intravenous injection into rats of m‐AAT and c‐AAT purified from rat liver exhibited a biphasic clearance curve with an overall half‐life of 42 min and 4.7 hr, respectively.

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