Eva I. Vidins, Robert S. Britton, Alan Medline, Laurence M. Blendis, Yedy Israel, Hector Orrego – 1 May 1985 – Portal hypertension in alcoholic liver disease has been attributed to an increased resistance to blood flow either of sinusoidal or of postsinusoidal origin. The former should be accompanied by sinusoidal compression while the latter is expected to result in an increased or a normal sinusoidal diameter.

Elliott S. Vesell – 1 May 1985

Theresa L. Whiteside, Steven Lasky, Lusheng Si, David H. van Thiel – 1 May 1985 – Using monoclonal antibodies to surface antigens, we typed and quantitated the mononuclear cells (MNCs) infiltrating liver tissues from 23 patients with primary sclerosing cholangitis. The circulating T lymphocytes were also enumerated by flow cytometry in 12 of these patients. In blood, T lymphocytes and especially T8+ cells were decreasd. T cells were the major components of MNCs (78%) in portal tracts. Few of these cells were Tac+ or HLA‐DR+. Total MNCs (929 ± 90 vs.

Yukio Kamimoto, Seikoh Horiuchi, Sumio Tanase, Yoshimasa Morino – 1 May 1985 – Both cytosolic (c‐AAT) and mitochondrial (m‐AAT) isozymes of aspartate aminotransferase (EC 2.6.1.1) appear in serum in some diseases including hepatobiliary dysfunction. The present study aimed at elucidation of the mechanism by which AAT isozymes are cleared from blood. Intravenous injection into rats of m‐AAT and c‐AAT purified from rat liver exhibited a biphasic clearance curve with an overall half‐life of 42 min and 4.7 hr, respectively.

H. L. Mencken, Harold O. Conn – 1 May 1985

Aaron Lerner, Byung H. Park, Thomas M. Rossi, Emanual Lebenthal – 1 May 1985 – We measured IgG, IgM and IgA antibodies to cow's milk proteins: α‐casein, α‐lactalbumin, bovine serum albumin, β‐lactoglobulin‐a and β‐lactoglobulin‐b in the sera of 29 pediatric patients with liver disease. IgG antibodies to bovine serum albumin, β‐lactoglobulin‐a and β‐lactoglobulin‐b and IgA antibodies to α‐casein were elevated in most of the patients compared to age‐matched controls.

Massimo Colombo, Giorgio Annoni, Maria Francesca Donato, Dario Conte, Dino Martines, Maria Grazia Zaramella, Paolo A. Bianchi, Alberto Piperno, Claudio Tiribelli – 1 May 1985 – To assess the value of type III procollagen peptide (sPIIIP) as a marker of hepatic fibrosis, sera from 73 patients with alcohol‐related liver disease and 30 patients with idiopathic hemochromatosis (IHC) were studied by a specific radioimmunoassay. sPIIIP was increased in 87% of 30 patients with cirrhosis, in 16% of 32 with steatofibrosis but in none of 11 with steatosis.

Kazuhide Yamamoto, Igor Sherman, M. James Phillips, Murray M. Fisher – 1 May 1985 – The arterial terminations were studied by scanning electron microscopy of microvascular casts in rat, hamster and human livers. Important species differences were observed. In the rat, frequent anastomoses between the terminal hepatic arterioles and portal venules were observed, whereas a few arterioles terminated directly into sinusoids. On the contrary, no arterioportal venous anastomoses were demonstrated in the hamster and human livers.

Polly Feigl – 1 March 1985

Dale A. Schoeller, Alvin N. Kotake, George H. Lambert, Patricia S. Krager, Alfred L. Baker – 1 March 1985 – The phenacetin breath test (PBT) has been proposed as an alternative to the aminopyrine breath test (ABT) for the assessment of hepatic function. To investigate the clinical utility of the PBT, we compared the PBT with the ABT in 9 healthy subjects and 18 patients with biopsy‐proven liver disease.