A randomized comparison of metoclopramide and domperidone on plasma aldosterone concentration and on spironolactone‐induced diuresis in ascitic cirrhotic patients

Agesilao D‐Arienzo, Gabriella Ambrogio, Pasqualina Di Siervi, Enzo Perna, Giovanni Squame, Gabriele Mazzacca – 1 September 1985 – The effect of metoclopramide and domperidone, two dopamine antagonists, administered to cirrhotic patients with ascites and secondary hyperaldosteronism, was examined to evaluate the changes in plasma aldosterone levels and in spironolactone‐induced diuresis.

Hepatic mitochondrial oxidative metabolism in rats with chronic dietary iron overload

Bruce R. Bacon, Chanho H. Park, Gary M. Brittenham, Rosemary O‐Neill, Anthony S. Tavill – 1 September 1985 – We examined the effects of chronic dietary iron overload on hepatic mitochondrial oxidative metabolism. Experimental iron overload was produced by feeding rats a chow diet supplemented with carbonyl iron over a 7‐week period. Biochemical and histologic evaluations of liver tissue confirmed moderate degrees of hepatic parenchymal iron overload.

Function of the autonomic nervous system in patients with hepatic encephalopathy

Kurt Lenz, Heide Hörtnagl, Dieter Magometschnigg, Gunter Kleinberger, Wilfred Druml, Anton Laggner – 1 September 1985 – To obtain further pathophysiological details concerning the development of cardiovascular disturbances in severe liver disease, the state of the autonomic nervous system, the function of the baroreceptor reflex pathway and the responsiveness of the cardiovascular system to noradrenaline, angiotensin II and isoprenaline were investigated in 11 patients with hepatic encephalopathy and in 10 healthy control subjects.

Mitochondrial antibodies in primary biliary cirrhosis: Species and nonspecies specific determinants of M2 antigen

Jutta Lindenborn‐Fotinos, Harold Baum, Peter A. Berg – 1 September 1985 – Sera from patients with primary biliary cirrhosis reacted with four major bands in beef heart mitochondria and ATPase extract when analyzed by immunoblot after sodium dodecyl sulfate‐polyacrylamide gel electrophoresis. These four immunologically reactive bands corresponded to protein bands with molecular weights of about (a) 80,000; (b) 63,000; (c) 56,000; and (d) 43,000 to 46,000. An additional immunoreactive band was found with some high‐titered primary biliary cirrhosis sera at 36,000.

Regulation of the human immune response to HBsAg: Effects of antibodies and antigen conformation in the stimulation of helper T cells by HBsAg

Esteban Celis, Ikunoshin Kato, Richard W. Miller, Tse Wen Chang – 1 September 1985 – The role of accessory cells (antigen‐presenting cells) in binding HBsAg in the response of human T cells to this antigen was studied. Antibodies to HBsAg of IgG class increased significantly the amount of HBsAg that was captured and internalized by accessory cells in vitro. On the other hand, antibodies to HBsAg of IgM class or the F(ab‐)2 and Fab fragments of antibodies to HBsAg of IgG class did not modify the amount of HBsAg associated to these cells.

Drug‐induced hepatitis associated with anticytoplasmic organelle autoantibodies

Jean‐Claude Homberg, Nielsen Abuaf, Samir Helmy‐Khalil, Michel Biour, Raoul Poupon, Shamsul Islam, François Darnis, Victor Georges Levy, Pierre Opolon, Michel Beaugrand, Jacques Toulet, Gaby Danan, Jean‐Pierre Benhamou – 1 September 1985 – A study from five hepatology units documenting 157 cases of drug‐induced hepatitis and a second study from a laboratory of immunology which tested more than 100,000 sera permitted us to establish the frequency of antiorganelle antibodies and their diagnostic value in drug‐induced hepatitis.

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