Jean‐Claude Homberg, Nielsen Abuaf, Samir Helmy‐Khalil, Michel Biour, Raoul Poupon, Shamsul Islam, François Darnis, Victor Georges Levy, Pierre Opolon, Michel Beaugrand, Jacques Toulet, Gaby Danan, Jean‐Pierre Benhamou – 1 September 1985 – A study from five hepatology units documenting 157 cases of drug‐induced hepatitis and a second study from a laboratory of immunology which tested more than 100,000 sera permitted us to establish the frequency of antiorganelle antibodies and their diagnostic value in drug‐induced hepatitis.

Robert J. Fallon, Alan L. Schwartz – 1 September 1985

Masayasu Inoue – 1 September 1985

1 September 1985

1 September 1985

Mack C. Mitchell, James J. Potter, Esteban Mezey, Helmut K. Seitz, Siegrid Veith, Peter Czygan, Johann Bösche, Bernd Simon, Burkhard Simon, Roland Gugler – 1 September 1985

Catherine L. Troisi, F. Blaine Hollinger – 1 September 1985 – An IgM‐specific anti‐[anti‐HBs] antibody was detected by radioimmunoassay using anti‐IgM‐coated beads and 125I‐labeled anti‐HBs. This antiidiotype was found only in the sera of hepatitis B virus‐infected patients, both acute and chronic. However, not all HBsAg‐positive patients exhibited this reaction, and activity was correlated with the presence of HBeAg. Approximately 93% of sera that contained antiidiotype activity also contained HBeAg. Conversely, 70% of the sera positive for HBeAg reacted in the IgM assay.

Nicola Tavoloni, Fenton Schaffner – 1 July 1985 – To determine whether hepatic artery blood flow is essential in maintaining the function and structure of bile ductules/ducts, the acute effects of hepatic artery ligation on bile secretion and hepatic ultrastructure were examined in anesthetized, bile duct‐cannulated guinea pigs.

Anna Engström‐Laurent, Lars Lööf, Anders Nyberg, Torbjörn Schröder – 1 July 1985 – Recent animal studies show that endothelial cells in liver sinusoids are the main site for removal of sodium hyaluronate from the circulation. Few data with respect to hyaluronate metabolism are available in man. Serum hyaluronate levels were measured in 119 patients with liver disease by a sensitive assay. The hyaluronate level was significantly increased in liver cirrhosis, in comparison with healthy controls and with patients with noncirrhotic liver disease.

Thomas Zysset, Mark A. Polokoff, Francis R. Simon – 1 July 1985 – Mechanisms of alcoholic liver disease are still ill defined. We evaluated in two outbred lines of mice whether chronic ingestion of ethanol alters the lipid composition and/or enzyme activity of liver plasma membranes. Two mouse lines with different sensitivities towards the hypnotic effect of ethanol, designated long sleep and short sleep, were fed a liquid diet containing ethanol for 30 days. Ethanol intake reached 30 gm per kg per day in both lines, and serum ethanol levels were similar.