Electron microscopy of rejected human liver allografts

Robert H. Fennell, John M. Vierling – 1 November 1985 – Recognition by biopsy of liver allograft rejection has been less successful than diagnosis of rejection of cardiac and kidney allografts. In a study of 138 failed liver allografts, we recognized damage to small interlobular bile ducts by lymphocytes as the most useful indicator of the presence of rejection. This is a report of the electron microscopic features of three patients with unequivocal allograft rejection. Lymphocytes and occasional granulocytes penetrated the epithelia of interlobular bile ducts.

Histopathology of early and late human hepatic allograft rejection: Evidence of progressive destruction of interlobular bile ducts

John M. Vierling, Robert H. Fennell – 1 November 1985 – Cholestasis and injury of interlobular bile ducts occur during rejection of human hepatic allografts. However, knowledge of the nature and progression of bile duct injury during rejection remains incomplete. To define the role of inflammation in bile duct damage, we assessed the light microscopic appearance of hepatic tissue from selected patients in whom allograft failure was solely due to rejection. Nine patients with rejection were easily separated into two groups based on the duration of the allograft survival.

Congenital portacaval shunt in rats: Liver adaptation to lack of portal vein—a light and electron microscopic study

Paulette Bioulac‐Sage, Jean Saric, Lilianne Boussarie, Charles Balabaud – 1 November 1985 – In five rats with congenital portacaval shunt, liver atrophy, hyperplastic foci in the periportal zone, atrophic hepatocytes in the centrolobular zone, well‐preserved hepatocyte ultrastructure with abundant rough endoplasmic reticulum, packed mitochondria and numerous peroxisomes were observed as in surgical portacaval shunt. However, portal triads were abnormal in contrast to surgical shunt. In large portal triads, hepatic arteries were prominent, bile ducts numerous and portal veins were lacking.

Halothane hepatitis without halothane: Role of inapparent circuit contamination and its prevention

Rajiv R. Varma, Robert C. Whitesell, Marwan M. Iskandarani – 1 November 1985 – Halothane and other halogenated anesthetic agents are liquids which are highly soluble in rubber and plastic materials widely used as components of anesthesia machines. These agents must be administered using machines equipped with vaporizers. We report a patient with a past history of halothane hepatitis in whom recurrence was suspected despite the fact that halothane had been avoided purposely during the subsequent operation.

Acute fatty liver of pregnancy: A clinicopathologic study of 35 cases

Donald B. Rolfes, Kamal G. Ishak – 1 November 1985 – Acute fatty liver of pregnancy is a disease of the third trimester which is generally considered to be rare and to have a grave prognosis. This study found an optimistic outlook for patients with acute fatty liver of pregnancy due to early termination of the pregnancy as well as the recognition of milder cases. In prospectively followed women, a maternal mortality of 8% and a fetal mortality of 14% were observed.

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