Mark D. Cohen, Lewis J. Rubin, Wayne E. Taylor, Jennifer A. Cuthbert – 1 January 1983 – A patient with both extrahepatic portal hypertension and primary pulmonary hypertension is reported. The pulmonary hypertension developed without a surgical portal‐systemic shunt, and at autopsy there was no evidence of a large spontaneous shunt. This association of pulmonary arterial hypertension and portal venous hypertension without either intrinsic liver disease or a large portal‐systemic anastomosis has not been reported previously.

Richard K. Fuller, Charles L. Hoppel – 1 January 1983 – Carnitine is essential for the oxidation of fatty acids. The liver is a major site of fatty oxidation. To determine if there are alterations in plasma carnitine in patients with alcoholic cirrhosis, we measured plasma carnitine and its metabolites by a specific radioenzymatic method in 20 men with hepatic cirrhosis and 30 healthy volunteers. We found total carnitine, free carnitine, short‐chain acylcarnitines, and long‐chain acylcarnitines to be significantly elevated in the cirrhotic subjects.

Patricia L. Marion, Susan S. Knight, Felix H. Salazar, Hans Popper, William S. Robinson – 1 January 1983 – Twenty‐four adult Beechey ground squirrels persistently infected with the hepatitis B virus‐related ground squirrel hepatitis virus (GSHV) remained infected with high levels of viral surface antigen (GSHsAg) and virion‐associated DNA polymerase activity in the blood for over 2 years in captivity.

1 January 1983

1 January 1983

Charles S. Davidson – 1 January 1983

Susan Webb, David Kravetz, Jaume Bosch, John A. H. Wass, Joan Evans, Ramon Gomis, Lesley H. Rees, Joan Rodes – 1 January 1983 – Experimental data suggest that somatostatin is metabolized by both liver and kidneys. Results in humans are conflicting. By studying a group of cirrhotic patients with surgically induced end‐to‐side portacaval shunts, basally and during a somatostatin infusion, we have been able to analyze separately the hepatic and splanchnic metabolism of this peptide. After catheterization, samples were obtained from the pulmonary artery, portal and hepatic veins.

Morris Sherman, John A. H. Campbell, Sally A. Titmuss, Michael C. Kew, Ralph E. Kirsch – 1 January 1983 – Qualitative and quantitative changes in glutathione S‐transferase (GSH‐T) were studied in human hepatocellular carcinoma. GSH‐T specific activity (/imoles per min per mg protein) was variably reduced in hepatocellular carcinoma. Similar changes were seen in “cationic” GSH‐T (ligandin) concentration determined by radioimmunoassay. Immunohistochemical studies with antihuman liver ligandin suggest that positive staining was more frequently found in well‐differentiated tumors.

Robert E. Shank – 1 January 1983

Dominique Bernuau, Edith Rogier, Gérard Feldmann – 1 January 1983 – During the acute inflammatory reaction (AIR), the plasma concentration of several plasma proteins, including fibrinogen, is increased as a result of enhanced production by the liver. Whether this increased production influences the production of the other plasma proteins at the single hepatocyte level is not known.