Chia‐Ming Chu, Yun‐Fan Liaw, I‐Shyan Sheen, Deng‐Yn Lin, Miau‐Ju Huang – 1 January 1983 – Hepatitis B e antigen (HBeAg) and antibody (anti‐HBe) were studied by radioimmunoassay in consecutive series of 145 asymptomatic hepatitis B surface antigen (HBsAg) carriers, 389 patients with HBsAg‐positive chronic liver disease and 194 patients with HBsAg‐positive hepatocellular carcinoma, and compared between male and female subjects. The male to female ratio increased from 1.2 in asymptomatic carriers to 6.3 in chronic liver disease and 9.8 in hepatocellular carcinoma.

Lis Fauerholdt, Poul Schlichting, Erik Christensen, Hemming Poulsen, Niels Tygstrup, Erik Juhl, The Copenhagen Study Group FOR Liver Diseases – 1 January 1983 – The conversion from micro‐ to macronodular cirrhosis is claimed to be a general phenomenon. In this study, the conversion was quantitated by means of liver needle follow‐up biopsies and autopsy in 156 patients followed in a controlled clinical trial of prednisone treatment in cirrhosis.

1 January 1983

Robert A. F. M. Chamuleau, Robert J. Popken, Ellen C. Beyerbacht, Henk W. M. De Koning – 1 January 1983 – Acute hepatic failure was induced in rats by galactosamine injection intraperitoneally (1 gm per kg). Twenty‐four hours later rats were treated by hemoperfusion (HP) over encapsulated sorbents: cellulose acetate‐coated charcoal, polyelectrolyte‐coated XAD4, a combination of both, or cross circulation with a healthy donor. Compared with control treatment (prevention of hypoglycemia by glucose infusion), the survival rate was not improved by HP or cross circulation: controls 19% vs.

1 January 1983

Reinhart Zachoval, Michael Roggendorf, Friedrich Deinhardt – 1 January 1983 – By routine screening for serologic markers of hepatitis A and B in patients with acute hepatitis, 30 chronic carriers of hepatitis B virus with serologic evidence of acute hepatitis A and two patients with simultaneous acute infection with hepatitis A virus and hepatitis B virus were detected.

Esteban Mezey, Charles S. Davidson – 1 January 1983

Yasuni Nakanuma, Goroku Ohta – 1 January 1983 – The number of granulomas and loosely arranged epithelioid cell foci in wedge liver biopsy specimens of 39 patients with primary biliary cirrhosis were counted and correlated with other hepatic lesions. Granulomas and cell foci were present in 76.9 and 87.2% of the patients, respectively; their numbers varied greatly from case to case (mean ± S.D.: 2.4 ± 3.4 per cm2 and 4.7 ± 5.5 per cm2 of liver section; range: 0 to 18.5 per cm2 and 0 to 23.3 per cm2, respectively) and decreased as bile duct loss progressed.

Pierre‐Michel Huet, Jean‐Pierre Villeneuve – 1 January 1983 – The effects of alterations of the hepatic blood flow, the intrinsic clearance, and the anatomy of the portal circulation on drug disposition were investigated in 53 cirrhotic patients with portal hypertension using indocyanine green (ICG) and lidocaine as model drugs. ICG disposition was studied by sampling from an artery and one hepatic vein following i.v. injection, with determination of systemic and intrinsic clearances and hepatic blood flow. Lidocaine disposition was studied following i.v.

Merrill C. Johnson – 1 January 1983