Gary Gitnick, Steven Weiss, Lacy R. Overby, Chung‐Mei Ling, Ruben Chairez, Khosrow Parsa – 1 January 1983 – An outbreak of non‐A, non‐B hepatitis (NANBH) in a hemodialysis unit was prospectively studied and the clinical, biochemical, and serologic events were correlated with an experimental immunodiffusion assay for serum antigen and antibody. One hundred sixteen subjects (76 dialysis patients and 40 staff members) were studied over an 8‐month period.

John A. Balint – 1 January 1983

John Wahren, Jacques Denis, Philippe Desurmont, Ljusk S. Eriksson, Jean‐Marc Escoffier, André P. Gauthier, Lars Hagenfeldt, Henri Michel, Pierre Opolon, Jean‐Claude Paris, Michel Veyrac – 1 January 1983 – The influence of intravenous infusion of branched‐chain amino acids (BCAAs) on brain function in patients with liver cirrhosis and acute hepatic encephalopathy was examined using a double‐blind, randomized study design. Five medical centers in France and Sweden participated, and 50 patients were studied.

Sheila Sherlock, Howard C. THomas – 1 January 1983 – Assays for the detection of nucleic acid in serum are likely to be better systems for determining infectivity than indirect ones dependent on detection of virus‐encoded proteins such as HBeAg. The hybridization assays are particularly useful in monitoring spontaneous or treatment‐related conversion from the “replicative” to “nonreplicative” phase of HB V infection.

Clifford J. Steer, Richard D. Klausner – 1 January 1983

Elie S. Zafrani, Bernard Leclercq, Jean‐Paul Vernant, Yvon Pinaudeau, Guy Chomette, Daniel Dhumeaux – 1 January 1983 – The clinical and pathological findings in four cases of fulminant hepatic failure due to massive infiltration of the liver by acute leukemia or lymphoma are reported. Liver abnormalities were found simultaneously with or led to the discovery of hematologic malignancies, and consisted of marked hepatomegaly and severe hepatocellular insufficiency associated with hyperlactatemia. The blood malignancies were peculiar in their fast cellular growth and large tumor mass.

Felix Witassek, Johannes Bircher, Philipp Huguenin, Rudolf Preisig – 1 January 1983 – The disposition of zomepirac was investigated in 18 patients with various liver diseases and in 10 healthy normal subjects in order to further test the hypothesis that glucuronidation of drugs may be spared in liver disease. Severity of the liver disease was assessed by the galactose elimination capacity. Following oral administration of zomepirac (200 mg), plasma and urinary drug concentrations were measured by high‐pressure liquid chromatography. Urine was assayed before and after alkaline hydrolysis.

Jay H. Lefkowitch, Kuo‐Ching Feng‐Chen, Jeffrey A. Sklar, Maureen B. Poh‐Fitzpatrick – 1 January 1983 – We studied the effects of cholic acid treatment on hepatic histology and ultrastructure in mice with griseofulvin‐induced protoporphyria. After 5 weeks of feeding griseofulvin alone, control mice developed darkly pigmented livers which by light microscopy showed birefringent, brown pigment deposits in bile ducts and ductules, sinusoidal Kupffer cell aggregates, and occasionally in hepatocytes and bile canaliculi.

Marshall M. Kaplan, Akiyuki Ohkubo, Elaine G. Quaroni, Duncan Sze‐Tu – 1 January 1983 – The following studies were done to determine the mechanism of the increse in rat liver alkaline phosphatase activity after bile duct ligation. Antiserum was raised in rabbits to highly purified rat liver alkaline phosphatase. In immune titration experiments, the 350% increase in rat liver alkaline phosphatase activity caused by bile duct ligation was paralleled by a similar increase in immuno‐precipitated alkaline phosphatase protein.

Alec Avgerinos, Peter Chu, Charles Greenfield, David S. Harry, Neil Mcintyre – 1 January 1983 – Serum lipids and lipoproteins were analyzed after an overnight fast, and following a fatty meal in 10 patients with cirrhosis, 5 with fatty liver, and 5 normal subjects. Cirrhotic patients were divided into two groups of five on the basis of serum lecithin‐cholesterol acyltransferase activity. Fasting triglyceride levels were similar in all four groups.