Marcello Piazza, Vincenzo Guadagnino, Ludovico Picciotto, Renato De Mercato, Antonio Chirianni, Raffaele Orlando, Gerard Golden – 1 January 1983 – A double‐blind trial was carried out on 124 randomized patients with acute viral hepatitis, of whom 58 were treated with (+)‐cyanidanol‐3 in a dose of 3 gm per day and 66 with placebo. The treatment was given for 50 days. At 5‐day intervals, SGPT, SGOT, and total serum bilirubin levels were tested.

Samuel W. French, Boris H. Ruebner, Esteban Mezey, Tsunenobu Tamura, Charles H. Halsted – 1 January 1983 – The effect of chronic ethanol feeding on hepatic mitochondrial morphology and histochemically measured succinic dehydrogenase activity was assessed. Five monkeys of the species Macaca radiata received a nutritionally adequate diet containing 50% of the calories as ethanol, while five others were pair‐fed the same diet except that ethanol was isocalorically substituted by carbohydrate.

Françoise Roudot‐Thoraval, Marc Halphen, Dominique Larde, Martine Galliot, Jean‐Claude Rymer, Frederic Galacteros, Daniel Dhumeaux – 1 January 1983 – The therapeutic management of patients with idiopathic hemochromatosis (IH) implies the evaluation of excess hepatic iron. This work was undertaken to confirm the value of computed tomography for the assessment of liver iron overload in such patients and to evaluate this technique during the course of treatment by phlebotomy.

Harold O. Conn – 1 January 1983

Alex W. Marshall, David Kingstone, Margot Boss, Marsha Y. Morgan – 1 January 1983 – Ethanol pharmacokinetics were determined following oral ethanol, 0.5 gm per kg, in nine normal women and 10 normal men, and related to total body water measured by 3H‐water dilution and body fat determined anthropometrically. Ethanol pharmacokinetics were similar in the females throughout the menstrual cycle. No variation was seen in mean peak blood ethanol concentration or elimination rate in the midfollicular (Days 8 to 10) and midluteal (Days 22 to 24) phases.

Gary Gitnick, Steven Weiss, Lacy R. Overby, Chung‐Mei Ling, Ruben Chairez, Khosrow Parsa – 1 January 1983 – An outbreak of non‐A, non‐B hepatitis (NANBH) in a hemodialysis unit was prospectively studied and the clinical, biochemical, and serologic events were correlated with an experimental immunodiffusion assay for serum antigen and antibody. One hundred sixteen subjects (76 dialysis patients and 40 staff members) were studied over an 8‐month period.

John A. Balint – 1 January 1983

John Wahren, Jacques Denis, Philippe Desurmont, Ljusk S. Eriksson, Jean‐Marc Escoffier, André P. Gauthier, Lars Hagenfeldt, Henri Michel, Pierre Opolon, Jean‐Claude Paris, Michel Veyrac – 1 January 1983 – The influence of intravenous infusion of branched‐chain amino acids (BCAAs) on brain function in patients with liver cirrhosis and acute hepatic encephalopathy was examined using a double‐blind, randomized study design. Five medical centers in France and Sweden participated, and 50 patients were studied.

Sheila Sherlock, Howard C. THomas – 1 January 1983 – Assays for the detection of nucleic acid in serum are likely to be better systems for determining infectivity than indirect ones dependent on detection of virus‐encoded proteins such as HBeAg. The hybridization assays are particularly useful in monitoring spontaneous or treatment‐related conversion from the “replicative” to “nonreplicative” phase of HB V infection.

Clifford J. Steer, Richard D. Klausner – 1 January 1983