Maria Anna Leo, Charles S. Lieber – 1 January 1983 – Rats were fed up to 9 months diets supplemented with vitamin A in an amount that, by itself, had no apparent adverse effect on the liver. When associated with chronic ethanol administration, vitamin A supplementation strikingly exacerbated ethanol‐induced abnormalities: fat accumulation was increased and numerous giant mitochondria were observed. Furthermore, lesions appeared which ethanol alone does not produce in rats, namely necrosis, inflammation, and fibrosis.

Hans Popper – 1 January 1983

Namiki Izumi, Yasushi Hasumura, Jugoro Takeuchi – 1 January 1983 – Renal tubular damage, in particular, renal tubular acidosis is associated with primary biliary cirrhosis (PBC), but hypouricemia has not been described. We studied four patients with PBC whose serum uric acid levels were 1.4 to 1.8 mg per dl, and compared their renal and liver functions with those of 11 patients with PBC whose serum uric acid levels were normal. In the patients with PBC and hypouricemia, uric acid clearance (Cua) and the ratio of Cua and creatinine clearance (Cua/Ccr) were high enough to cause hypouricemia.

Herbert De Groot, Thomas Noll – 1 January 1983

Rita De Vos, Marie J. Vanstapel, Jan Desmyter, Chris De Wolf‐Peeters, Guy De Groote, Jan Colaert, Jan Mortelmans, Jan De Groote, Johan Fevery, Valeer Desmet – 1 January 1983 – This study reports the findings of an electron microscopic search for so‐called non‐A, non‐B nuclear particles in liver biopsies from patients with mainly chronic or prolonged liver disease and from chimpanzees.

A. De Margreet Leeuw, Adriaan Brouwer, Roel J. Barelds, Dick L. Knook – 1 January 1983 – Sinusoidal liver cells were isolated from the livers of 3‐, 12‐, 30‐, and 36‐month‐old female BN/ BiRij rats by enzymatic digestion. The Kupffer cells in the sinusoidal eel suspensions were purified by centrifugal elutriation and kept in maintenance culture for periods of up to about 3 weeks. The viability and yield of Kupffer cells per gram of body weight did not change with the age of the donor rat.

John E. Coe, Kamal G. Ishak, Mary J. Ross – 1 January 1983 – An unusual and impressive hyperbilirubinemia was induced in Chinese hamsters by administration of diethylstilbestrol (DES). This icterus was dose‐dependent and affected females more severely than males. However, a similar mortality was detected in both sexes. Another hamster, the Armenian hamster, was even more susceptible to the icteric and lethal effects of DES. The hamster model of DES‐induced icterus showed many clinical dissimilarities when compared to the human estrogen‐induced jaundice, simple cholestatic jaundice.

John R. Senior – 1 January 1983

1 January 1983

E. Anthony Jones – 1 January 1983