Ruy Perez Tamayo – 1 January 1983

Earl F. Meierhenry, Boris H. Ruebner, M. Eric Gershwin, Lucy S. Hsieh, Samuel W. French – 1 January 1983 – Mallory bodies (MBs) were induced in hepatic tumors by administration for up to 85 weeks of a diet containing 10 ppm dieldrin to 50 C3H/He and 62 C57BL/6J X C3H/He B6C3F1 male mice. MBs were seen in 15 of 28 (54%) mice which developed benign hepatic tumors and 33 of 45 (73%) mice with hepatocellular carcinoma, but in only 3 of 39 (8%) mice without hepatic tumors.

Daniel Mirouze, Robert D. Zipser, Telfer B. Reynolds – 1 January 1983 – The effect of inhibitors of prostaglandin synthesis on diuretic action was examined in patients with ascites due to chronic liver disease and in normal subjects. In patients with ascites, natriuresis after 80 mg i.v. furosemide was reduced 82% by pretreatment with indomethacin. Creatinine clearance was reduced only 16%. These effects were likely due to inhibition of renal prostaglandin synthesis, since urinary prostaglandin E2 fell and there was also reduction in natriuresis with naproxen (52%).

Maria Anna Leo, Charles S. Lieber – 1 January 1983 – Rats were fed up to 9 months diets supplemented with vitamin A in an amount that, by itself, had no apparent adverse effect on the liver. When associated with chronic ethanol administration, vitamin A supplementation strikingly exacerbated ethanol‐induced abnormalities: fat accumulation was increased and numerous giant mitochondria were observed. Furthermore, lesions appeared which ethanol alone does not produce in rats, namely necrosis, inflammation, and fibrosis.

Hans Popper – 1 January 1983

Namiki Izumi, Yasushi Hasumura, Jugoro Takeuchi – 1 January 1983 – Renal tubular damage, in particular, renal tubular acidosis is associated with primary biliary cirrhosis (PBC), but hypouricemia has not been described. We studied four patients with PBC whose serum uric acid levels were 1.4 to 1.8 mg per dl, and compared their renal and liver functions with those of 11 patients with PBC whose serum uric acid levels were normal. In the patients with PBC and hypouricemia, uric acid clearance (Cua) and the ratio of Cua and creatinine clearance (Cua/Ccr) were high enough to cause hypouricemia.

Herbert De Groot, Thomas Noll – 1 January 1983

Rita De Vos, Marie J. Vanstapel, Jan Desmyter, Chris De Wolf‐Peeters, Guy De Groote, Jan Colaert, Jan Mortelmans, Jan De Groote, Johan Fevery, Valeer Desmet – 1 January 1983 – This study reports the findings of an electron microscopic search for so‐called non‐A, non‐B nuclear particles in liver biopsies from patients with mainly chronic or prolonged liver disease and from chimpanzees.

A. De Margreet Leeuw, Adriaan Brouwer, Roel J. Barelds, Dick L. Knook – 1 January 1983 – Sinusoidal liver cells were isolated from the livers of 3‐, 12‐, 30‐, and 36‐month‐old female BN/ BiRij rats by enzymatic digestion. The Kupffer cells in the sinusoidal eel suspensions were purified by centrifugal elutriation and kept in maintenance culture for periods of up to about 3 weeks. The viability and yield of Kupffer cells per gram of body weight did not change with the age of the donor rat.

John E. Coe, Kamal G. Ishak, Mary J. Ross – 1 January 1983 – An unusual and impressive hyperbilirubinemia was induced in Chinese hamsters by administration of diethylstilbestrol (DES). This icterus was dose‐dependent and affected females more severely than males. However, a similar mortality was detected in both sexes. Another hamster, the Armenian hamster, was even more susceptible to the icteric and lethal effects of DES. The hamster model of DES‐induced icterus showed many clinical dissimilarities when compared to the human estrogen‐induced jaundice, simple cholestatic jaundice.