Eberhard Renner, Hubertus Wietholtz, Philipp Huguenin, Maurice J. Arnaud, Rudolf Preisig – 1 January 1984 – The effects of liver disease on caffeine plasma clearance (CI) and on exhalation of 14CO2 following i.v. injection of 2 μCi of [ 3‐methyl‐14C]caffeine together with 125 mg of the unlabeled compound were measured in 15 patients with cirrhosis, 11 subjects with miscellaneous liver disease, and 10 normal volunteers. Compared to mean values for CI (2.02 ± S.D.

David H. Van Thiel, Robert R. Schade, Judith S. Gavaler, Byers W. Shaw, Shunzaburo Iwatsuki, Thomas E. Starzl – 1 January 1984 – The methods used to screen prospective candidates for orthotopic liver transplantation are described. Both the indication and the contraindications for the procedure are discussed. The timing of the procedure during the course of an individual candidate's liver disease is also discussed. Additionally, the institutional requirements of a liver transplant center are identified.

Willis C. Maddrey – 1 January 1984 – Hepatic vein thrombosis (Budd‐Chiari Syndrome) is a rare disorder resulting from obstruction to the outflow of blood from the liver. The characteristic pathologic findings are intense congestion most pronounced around the terminal hepatic venules, cell necrosis, and a scant inflammatory reaction. Major clinical manifestations include hepatomegaly, right upper quadrant abdominal pain, and ascites.

Daniel Alagille – 1 January 1984 – Liver disease related to a–1–antitrypsin deficiency occurs only in Pi ZZ homozygous children. Eleven per cent of Pi ZZ infants present with prolonged neonatal cholestasis. In our group, 25 of 45 Pi ZZ infants with prolonged neonatal cholestasis presented with later cirrhosis. Persistence of jaundice beyond the sixth month of age, early development of splenomegaly, persistence of hard hepatomegaly and liver function abnormalities, and early portal fibrosis have a poor prognostic significance.

1 January 1984

Keith Rolles, Roger Williams, James Neuberger, Roy Calne – 1 January 1984 – The postoperative course of 138 transplants performed in 137 patients in the Cambridge and King's College Hospital series between May 2, 1968 and April 1, 1983 is presented. During the last 15 years, criteria for selection of transplant candidates has been improved and types of disease categories, both suitable and unsuitable for liver transplantation, have been defined.

David R. Beswick, James L. Boyer – 1 January 1984

Irwinm Arias, Hans Popper – 1 January 1984

Phillip H. Stoltenberg, Ronald D. Soltis – 1 January 1984 – Circulating immune complexes have been described in most liver diseases, including alcoholic liver disease, although their pathogenic significance remains unclear. Currently available immune complex assays do not distinguish immunoglobulin aggregates from antigen‐antibody complexes. Immunoglobulin aggregate formation occurs in vitro at 37°C in the presence of hypergammaglobulinemia and/or hypoalbuminemia, conditions common in liver disease.

Wolfgang Grauer, Norbert W. Brattig, Hans Schomerus, Gerd FrÖSner, Peter A. Berg – 1 January 1984 – Two immunosuppressive serum factors, serum inhibition factor (SIF) and rosette inhibitory factor (RIF), were studied in sera from patients with acute and chronic viral hepatitis. In a study of 30 patients with acute viral hepatitis, an association was found between RIF, SIF, and biochemical and virological parameters in 27 patients (90%), 25 of whom recovered completely; two had a protracted course. In three patients, the clinical course was not reflected by the immunosuppressive factors.