Gary C. Kanel, Robert L. Peters – 1 March 1984 – The hepatorenal syndrome, a primary cause of death from acute and chronic liver disease, consists of a functional renal failure whereby examination of the kidney has previously shown no distinct or specific morphologic change. We describe an unusual renal lesion consisting of the reflux of proximal convoluted tubular epithelium into Bowman's space. An autopsy series shows this glomerular change to be present in 71.4% of cases with the hepatorenal syndrome, while only present in 0 to 27.3% in other autopsy categories (p < 0.001).

Gerald Y. Minuk, John Vergalla, Peter Ferenci, E. Anthony Jones – 1 March 1984 – γ‐Aminobutyric acid (GABA) is a potent inhibitory neurotransmitter which is synthesized by the enteric bacterial flora and delivered into portal venous blood. To determine whether the liver is likely to play an important role in regulating serum GABA levels, the uptake and metabolism of [3H]GABA by three populations of cells isolated from rat liver were studied. GABA was specifically taken up by hepatocytes but not by endothelial or Kupffer cells.

1 March 1984

Charles S. Davidson – 1 March 1984

John Gollan, Antony Mcdonagh – 1 March 1984

Hiroshi Murakami, Junsuke Kuriki, Shinichi Kakumu, Kazuhiko Fukui, Nobuo Sakamoto – 1 March 1984 – Hybrid cell lines which secreted antibodies to liver‐specific membrane lipoprotein (LSP) were obtained by immunizing SMA and BALB/c mice with human LSP and fusing their splenocytes with the myeloma cell line P 3‐NSI/l‐Ag 4‐l.

Peter Ferenci, S.Chris Pappas, Peter J. Munson, Ken Henson, E. Anthony Jones – 1 March 1984 – It has previously been shown in an animal model of hepatic encephalopathy (HE) that the number of receptors for the inhibitory neurotransmitter, γ‐aminobutyric acid (GABA), increases and that the number of receptors for the excitatory neurotransmitter, glutamate, decreases.

Nikolai V. Naumov, Mario Mondelli, Graeme J. M. Alexander, Richard S. Tedder, Adrian L. W. F. Eddleston, Roger Williams – 1 January 1984 – Previous studies demonstrated that peripheral blood lymphocytes are cytotoxic to autologous hepatocytes in patients with chronic hepatitis B virus infection. We examined whether cytotoxicity is specifically directed against hepatocytes expressing HBsAg or HBcAg.

Antoni Rimola, Ramón Soto, Felipe Bory, Vicente Arroyo, Carlos Piera, Joan Rodes – 1 January 1984 – The reticuloendothelial system phagocytic activity, estimated by the plasma elimination rate constant of 99mtechnetium‐sulfur colloid, was studied in 41 decompensated cirrhotics and 10 normal subjects. The results were related to the incidence and type of bacterial infections occurring during hospitalization and follow‐up, and to survival.

Christopher J. Burrell, Eric J. Gowans, Robert Rowland, Pauline Hall, Allison R. Jilbert, Barrie P. Marmion – 1 January 1984 – Liver sections from 18 patients positive for hepatitis B surface antigen (HBsAg), and from 12 negative patients, were examined for the presence of hepatitis B virus (HBV) DNA using an in situ hybridization assay that would identify only those hepatocytes containing more than 10 to 15 HBV genome equivalents per cell. Such cells are likely to be undergoing active viral replication, rather than latent infection.