Didier Lebrec, Thierry Poynard, Jacques Bernuau, Eric Bercoff, Olivier Nouel, Jean‐Pierre Capron, Raoul Poupon, Michel Bouvry, Bernard Rueff, Jean‐Pierre Benhamou – 1 May 1984 – We have previously reported the results of a controlled trial showing that continuous oral administration of propranolol reduced the risk of recurrent gastrointestinal bleeding in patients with cirrhosis; only part of our patients had been followed for 1 year. This controlled trial was continued for an additional year; accordingly, all of our patients have now been followed for at least 2 years.

Eric Bercoff, Christian Bataille, Alexandre E. Pariente, Dominique Valla, Brigitte Delhotal, Didier Lebrec – 1 May 1984 – Fourteen patients with cirrhosis and bleeding esophageal varices were treated with propranolol. The dose of propranolol was determined by decreasing the resting heart rate by 25% 12 hr after an oral dose of propranolol which was given twice a day. Significant decreases in the hepatic venous pressure gradient and cardiac output after 1 month of propranolol administration was observed.

Premila Trivedi, M. Stuart Tanner, Bernard Portmann, Janet Mcclement, Alex P.

Anastasios A. Mihas, John E. Volanakis, Ralph E. Schrohenloher, Tony A. Mihas, Henry C. Bodenheimer, Nicholas F. Larusso, Walter R. Thayer, Colette Charland, Parker J. Staples, Jurgen Ludwig, M. Roggendorf, F. Deinhardt, Gert G. FrÖSner – 1 March 1984

Henry Brown – 1 March 1984

Spencer Shaw, Theresa M. Worner, Charles S. Lieber – 1 March 1984 – In alcohol‐induced liver injury, hyperprolinemia has been proposed as a marker of fibrogenesis probably secondary to hyperlactacidemia. However, some studies of plasma proline in alcoholics with cirrhosis have reported normal rather than increased levels.

Jose M. Bengoa, Michael D. Sitrin, Stephen Meredith, Susan E. Kelly, Nikunj Shah, Alfred L. Baker, Irwin H. Rosenberg – 1 March 1984 – Metabolic bone disease is common in patients with cholestatic liver disease. The importance of vitamin D status and calcium malabsorption in the pathogenesis of bone disease in these patients remains undefined. We have measured intestinal calcium absorption in relation to vitamin D status in 14 patients with chronic cholestatic liver disease including 11 with primary biliary cirrhosis.

Thierry Poynard, Othar Zourabichvili, Gerard Hilpert, Sylvie Naveau, Alain Poitrine, Clarisse Benatar, Jean‐Claude Chaput – 1 March 1984 – The aim of this study was to assess the prognostic value of total serum bilirubin (TSB), γ‐glutamyl transpeptidase (GGT) and the TSB/GGT ratio in 129 consecutive cirrhotic patients, and to determine how seven other clinical and biochemical variables affect the prognostic value of these measurements. The Cox model and log rank test were used to compare survival rates at 1 year.

Serge Erlinger, Alice Le Go, Jean‐Marc Husson, Johan Fevery – 1 March 1984 – A double‐blind randomized, multicenter study was carried out to determine the efficacy and safety of ursodeoxycholic acid (UDCA) at 4 doses of 2.1 to 16.2 mg‐kg−1 day−1, and chenodeoxycholic acid (CDCA) at the dose of 16.9 mg‐kg−1 ‐day−1, in 197 patients treated for up to 1 year for radiolucent gallstones in functioning (opacified) gallbladders.

Mario Frezza, Gabriele Pozzato, Lucio Chiesa, Giorgio Stramentinoli, Carlo Di Padova – 1 March 1984 – Previous investigations have indicated that S‐adenosyl‐L‐methionine (SAMe) leads to reversal of estrogen‐induced bile flow impairment in rats. This randomized, single‐blind clinical trial was performed to determine whether SAMe reverses intrahepatic cholestasis of pregnancy (ICP) which occurs in hypersensitive women associated with increased estrogen levels in late pregnancy.