Alton Meister – 1 July 1984

Pedro Valencia‐Mayoral, James Weber, Ernest Cutz, Vernon D. Edwards, M. James Phillips – 1 July 1984 – Ultrastructural observations on 12 liver biopsies from 10 patients with arteriohepatic dysplasia syndrome (Alagille's syndrome) are reported. The electron microscopic changes in the liver in this condition are different from those seen in other forms of chronic intra‐ and extrahepatic cholestasis. In particular, the bile canalicular and pericanalicular changes classically observed in cholestasis are infrequently seen.

Ernest Song, Geoffrey M. Dusheiko, Sheila Bowyer, Michael C. Kew – 1 July 1984 – Sera from 106 southern African blacks with hepatocellular carcinoma and hepatitis B surface antigenemia (HBsAg) were tested for hepatitis B viral DNA (HBV‐DNA) activity, HBV‐DNA polymerase concentrations, and HBV e antigen (HBeAg) and antibody (anti‐HBe) to investigate the state of viral replication in these patients.

Masao Omata, Osamu Yokosuka, Fumio Imazeki, Yasuhisa Matsuyama, Katsuo Uchiumi, Yoshimi Ito, Junko Mori, Kunio Okuda – 1 July 1984 – Human hepatitis B‐like viruses have been found in several animal species, including Chinese ducks. Sera from Chinese carrier ducks which were positive for duck hepatitis B virus (DHBV) were inoculated in 33 Japanese one‐day‐old ducklings. The same sera were inoculated in four 3‐week‐old ducklings, and three 3‐month‐oId ducks. Ten uninoculated ducklings served as controls.

Maria H. Sjogren, Stanley M. Lemon, Whan K. Chung, Hee S. Sun, Jay H. Hoofnagle – 1 July 1984 – Primary hepatocellular carc1inoma (PHC) has been linked etiologically to persistent hepatitis B virus (HBV) infections by epidemiologic, serologic and molecular lines of evidence. To evaluate the frequency of IgM antibody to the viral core antigen (IgM anti‐HBc) detected by a highly sensitive radioimmunoassay, we compared 110 Korean patients with PHC to a group of 63 age‐and sex‐matched control patients with other tumors. Results were correlated with those of commercially available HBV assays.

1 July 1984

Albert J. Czaja, Gary L. Davis, Jurgen Ludwig, Howard F. Taswell – 1 July 1984 – To assess the frequency and significance of complete resolution of inflammatory activity following corticosteroid therapy, 115 patients with severe HBsAg‐negative chronic active hepatitis were followed regularly for 84 ± 5 months. Of 83 patients eligible to revert to normal liver tissue, 18 did so after 56 ± 8 months. Five of the 18 relapsed after treatment withdrawal.

Gilles Duhamel, Bertrand Nalpas, Sonia Goldstein, P. Michel Laplaud, Pierre Berthelot, M. John Chapman – 1 July 1984 – In the present study, we report on alterations in plasma lipid, lipoprotein and apolipoprotein patterns in three separate populations of alcoholic patients, one without liver damage (Group I), a second presenting steatosis or mild alcoholic hepatitis or both (Group II) and a third with alcoholic cirrhosis (Group III), using a healthy, normolipidemic, nonalcoholic group as controls (Group C).

William W. Faloon – 1 July 1984

Ardythe A. Mccracken, Merrill Emmett, Alfred J. Crowle, Jerry L. Brown – 1 July 1984 – We have used crossed Immunoelectrophoresis to identify and establish the relative amounts of serum proteins secreted by a differentiated cell line (Fao) derived from a Reuber H35 rat hepatoma. Our results show that these cells secrete at least 15 plasma proteins. Ten of these: albumin, α1‐antitrypsin, α1‐lipoprotein, α1‐macroglobulin, α1‐antichymotrypsin, GC‐globulin (transcalciferin), fibronectin, hemopexin, transferrin and the C3 component of complement have been identified.