Jose M. Bengoa, Michael D. Sitrin, Stephen Meredith, Susan E. Kelly, Nikunj Shah, Alfred L. Baker, Irwin H. Rosenberg – 1 March 1984 – Metabolic bone disease is common in patients with cholestatic liver disease. The importance of vitamin D status and calcium malabsorption in the pathogenesis of bone disease in these patients remains undefined. We have measured intestinal calcium absorption in relation to vitamin D status in 14 patients with chronic cholestatic liver disease including 11 with primary biliary cirrhosis.

Thierry Poynard, Othar Zourabichvili, Gerard Hilpert, Sylvie Naveau, Alain Poitrine, Clarisse Benatar, Jean‐Claude Chaput – 1 March 1984 – The aim of this study was to assess the prognostic value of total serum bilirubin (TSB), γ‐glutamyl transpeptidase (GGT) and the TSB/GGT ratio in 129 consecutive cirrhotic patients, and to determine how seven other clinical and biochemical variables affect the prognostic value of these measurements. The Cox model and log rank test were used to compare survival rates at 1 year.

Serge Erlinger, Alice Le Go, Jean‐Marc Husson, Johan Fevery – 1 March 1984 – A double‐blind randomized, multicenter study was carried out to determine the efficacy and safety of ursodeoxycholic acid (UDCA) at 4 doses of 2.1 to 16.2 mg‐kg−1 day−1, and chenodeoxycholic acid (CDCA) at the dose of 16.9 mg‐kg−1 ‐day−1, in 197 patients treated for up to 1 year for radiolucent gallstones in functioning (opacified) gallbladders.

Mario Frezza, Gabriele Pozzato, Lucio Chiesa, Giorgio Stramentinoli, Carlo Di Padova – 1 March 1984 – Previous investigations have indicated that S‐adenosyl‐L‐methionine (SAMe) leads to reversal of estrogen‐induced bile flow impairment in rats. This randomized, single‐blind clinical trial was performed to determine whether SAMe reverses intrahepatic cholestasis of pregnancy (ICP) which occurs in hypersensitive women associated with increased estrogen levels in late pregnancy.

Rosa M.

William M. Rand – 1 March 1984

Thomas S. Edgington – 1 March 1984

Attallah Kappas, George S. Drummond, Creuza S. Simionatto, Karl E. Anderson – 1 March 1984

Douglas Horst, Norman D. Grace, Harold O. Conn, Eugene Schiff, Steven Schenker, Alfredo Viteri, David Law, Colin E. Atterbury – 1 March 1984 – A randomized study was conducted in 37 hospitalized patients at six cooperating hospitals in which protein‐intolerant cirrhotic patients were fed increasing amounts of either dietary protein or a branched‐chain enriched amino acid solution (BCAA) until they attained an intake of 80 gm protein per day or equivalent or until they developed stage 2 encephalopathy.

Sohrab A. Mobarhan, Robert M. Russell, Robert R. Recker, David B. Posner, Frank L. Iber, Pamela Miller – 1 March 1984 – In a study of 56 alcoholics with liver cirrhosis, 18 (32%) had decreased bone density and low levels of serum 25‐hydroxyvitamin D (25‐OH‐D) (<20 ng per ml).