Skills and Resources Needed for Liver Transplantation

Ruud A. F. Krom, Chris H. Gips – 1 January 1984 – Trained specialists in hepatology, liver and biliary surgery, anesthesiology and pathology must form the core of a team for liver transplantation. The hospital must be a center for organ transplantation to provide the essential infrastructure to manage specific aspects of transplantation. A well‐organized blood bank is essential to cope with acute requests for large amounts of donor blood.

Chronic Hepatitis and Cirrhosis

Sheila Sherlock – 1 January 1984 – Chronic hepatitis is defined as diffuse chronic liver disease existing for at least 6 months. Cirrhosis is a sequel. It is of multiple etiology. Liver biopsy is essential for diagnosis and prognosis. Hepatitis B‐related chronic hepatitis is slowly progressive. Corticosteroid therapy is disappointing. Current antiviral therapy converts the hepatitis B e antigen‐positive patient to anti‐HBe in about 50%. Non‐A, non‐B virus hepatitis‐related chronic hepatitis suffers from lack of a diagnostic marker. No current therapy is of proven benefit.

Asialoglycoprotein Receptor Expression in Murine Pregnancy and Development

Janna C. Collins, Richard J. Stockert, Anatol G. Morell – 1 January 1984 – Hepatic asialoglycoprotein receptor activity of pregnant mice increased from the tenth day of gestation, reaching 3‐fold the normal adult level just prior to parturition and returning to normal within 1 week postpartum. Increases in activity involved both intracellular and cell‐surface associated receptors and were associated with enhanced endocytosis of asialoorosomucoid by isolated hepatocytes.

Inhibition of Bile Flow in the Isolated Perfused Rat Liver by a Synthetic Parenteral Amino Acid Mixture: Associated Net Amino Acid Fluxes

Martin F. Graham, Anthony S. Tavill, Thomas C. Halpin, Loizos N. Louis – 1 January 1984 – To identify a role for amino acids in cholestasis associated with total parenteral nutrition, we measured bile formation by the isolated perfused rat liver in the presence and absence of added amino acids. All livers were infused,constantly with sodium [14C]taurocholate (0.28 μmoles per min) for 90 min. At 40 min, a primed‐constant infusion of a synthetic L‐amino acid mixture (121 + 19.3 μmoles of N per min) was administered for an additional 50 min.

The Liver in Crigler‐Najjar Syndrome, Protoporphyria, and Other Metabolic Disorders

Joseph R. Bloomer, Harvey L. Sharp – 1 January 1984 – The liver may be involved in metabolic disorders in two ways, (i) Due to its critical role in several metabolic pathways, the liver may be the major site of expression of a biochemical abnormality. For example, in Type I Crigler‐Najjar syndrome, absence of hepatic bilirubin glucuronyl transferase activity causes severe unconjugated hyperbilirubinemia which invariably leads to death from kernicterus. (ii) The liver may also be structurally damaged by the metabolic disorder.

Hepatic Injury in the Toxic Epidemic Syndrome Caused by Ingestion of Adulterated Cooking Oil (Spain, 1981)

JosÉ A. Solis‐Herruzo, Gregorio Castellano, Francisco Colina, Juan Diego Morillas, Maria Teresamuñoz‐Yagüe, Maria Del Carmen Coca, Dusko Jelavic – 1 January 1984 – We describe the clinico‐pathological characteristics of hepatic injury associated with the toxic‐epidemic syndrome caused by the consumption of adulterated rapeseed oil. Of 842 toxic‐epidemic syndrome patients admitted to our hospital between May, 1981, and January, 1982, 24.1% showed signs of liver involvement which was more frequent in women and in the fourth decade of life.

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