Christopher J. Burrell, Eric J. Gowans, Robert Rowland, Pauline Hall, Allison R. Jilbert, Barrie P. Marmion – 1 January 1984 – Liver sections from 18 patients positive for hepatitis B surface antigen (HBsAg), and from 12 negative patients, were examined for the presence of hepatitis B virus (HBV) DNA using an in situ hybridization assay that would identify only those hepatocytes containing more than 10 to 15 HBV genome equivalents per cell. Such cells are likely to be undergoing active viral replication, rather than latent infection.

Antoni Rimola, Ramón Soto, Felipe Bory, Vicente Arroyo, Carlos Piera, Joan Rodes – 1 January 1984 – The reticuloendothelial system phagocytic activity, estimated by the plasma elimination rate constant of 99mtechnetium‐sulfur colloid, was studied in 41 decompensated cirrhotics and 10 normal subjects. The results were related to the incidence and type of bacterial infections occurring during hospitalization and follow‐up, and to survival.

Nikolai V. Naumov, Mario Mondelli, Graeme J. M. Alexander, Richard S. Tedder, Adrian L. W. F. Eddleston, Roger Williams – 1 January 1984 – Previous studies demonstrated that peripheral blood lymphocytes are cytotoxic to autologous hepatocytes in patients with chronic hepatitis B virus infection. We examined whether cytotoxicity is specifically directed against hepatocytes expressing HBsAg or HBcAg.

Robert H. , Fennell Jr, Robert H. Shikes, John M. Vierling – 1 January 1983 – Histopathological features of nonsuppurative destructive cholangitis have been described in primary biliary cirrosis, chronic graft‐vs.‐host disease, and chronic rejection of human liver allografts. To determine whether or not susceptibility to injury of interlobular bile ducts was related to the original hepatobiliary disease requiring transplantation, we compared the histopathology of allografts transplanted into two groups of patients.

Charles S. Davidson – 1 January 1983

Marisabel Mourelle, Javier Cordero‐Hernández, Patricia Ponce‐Noyola, Marcos Rojkind – 1 January 1983 – Liver biomatrix contains a group of connective tissue components needed for attachment, survival, and maintenance of liver‐specific functions of adult rat hepatocytes in culture. An acidic extract of liver biomatrix that contains a group of glycoproteins can replace intact biomatrix in promoting attachment and survival of hepatocytes. However, except for albumin synthesis, liver‐specific functions have not been tested.

Geoffrey Dusheiko, Ernest Song, Sheila Bowyer, Michael Whitcutt, Gunthild Maier, Anthony Meyers, Mlchael C. Kew – 1 January 1983 – Hepatitis B virus (HBV) markers were measured in 83 immunosuppressed renal transplant patients who were followed for periods of 2 to 15 years. Sixty‐nine patients were negative for HBsAg before transplantation, of whom 14 were positive for anti‐HBs. The remaining 14 patients were HBsAg positive prior to transplantation. Eighteen patients were identified as being HBsAg positive during the follow‐up period.

Gary C. Kanel, George Radvanand, Robert L. Peters – 1 January 1983 – To establish whether there is any significant relationship between high‐density lipoprotein cholesterol (HDLC) concentrations and biopsy‐documented liver disease, 169 patients had needle biopsies, serum cholesterol, and HDLC evaluated. Twenty‐four patients had serial cholesterol, HDLC, prothrombin, and aminotransferase levels and activities examined. In both men and women, HDLC decreased strikingly and significantly in acute alcoholic hepatitis and in acute viral hepatitis, compared to controls (p < 0.001).

William G. M. Hardison, Robin G. Weiner, David E. Hatoff, Katsumi Miyai – 1 January 1983 – Biliary obstruction in the rat causes known biochemical and morphological abnormalities. These abnormalities might be caused simply by retention of biliary constituents or might require other factors such as high biliary pressure, interruption of the normal flux of fluid, ions, and other biliary constituents through the hepatocyte and/or changes in intracellular concentrations, binding, and distribution of biliary constituents.

Sten Eriksson, Christer Larsson – 1 January 1983 – Three of four adult siblings in a family which was studied for three generations had clinical and/ or laboratory signs of slowly progressive intrahepatic cholestasis. Slight hyper pigmentation, facial hypertrichosis, and hypothyroidism were seen in affected individuals who also had prolonged increase in serum transaminase, γ‐glutamyltranspeptidase, and alkaline phosphatase activities.