William G. M. Hardison, Robin G. Weiner, David E. Hatoff, Katsumi Miyai – 1 January 1983 – Biliary obstruction in the rat causes known biochemical and morphological abnormalities. These abnormalities might be caused simply by retention of biliary constituents or might require other factors such as high biliary pressure, interruption of the normal flux of fluid, ions, and other biliary constituents through the hepatocyte and/or changes in intracellular concentrations, binding, and distribution of biliary constituents.

Sten Eriksson, Christer Larsson – 1 January 1983 – Three of four adult siblings in a family which was studied for three generations had clinical and/ or laboratory signs of slowly progressive intrahepatic cholestasis. Slight hyper pigmentation, facial hypertrichosis, and hypothyroidism were seen in affected individuals who also had prolonged increase in serum transaminase, γ‐glutamyltranspeptidase, and alkaline phosphatase activities.

Clyde Crumpacker – 1 January 1983

William V. Mcdermott – 1 January 1983

John E. Hegarty, Kayhan T. Nouri Aria, Bernard Portmann, Adrian L. W. F. Eddleston, Roger Williams – 1 January 1983 – A prospective study was performed to evaluate the outcome of treatment withdrawal in 30 patients with “autoimmune” chronic active hepatitis in remission for periods of 1.5 to 9 years on maintenance corticosteroid and azathioprine therapy. Reactivation of disease, with marked rises in serum aminotransferase level (mean 668 ± S.D.

Gabriele E. Schrempf‐Decker, Diethard P. Baron, Norbert W. Brattig, Hermann Bockhorn, Peter A. Berg – 1 January 1983 – The liver immunoregulatory protein (LIP) was originally characterized as human liver‐derived soluble factor which inhibited the alloantigen and phytohemagglutinin‐induced proliferation of human lymphocytes (1). Soluble extracts prepared under the same experimental conditions from kidney, spleen, heart, lymph nodes, and erythrocytes did not exert any inhibitory activity (2). The purpose of this study was to characterize the immunobiological properties of LIP.

Jaime Bosch, Rosa Enriquez, Roberto J. Groszmann, Edward H. Storer – 1 January 1983 – Splanchnic and systemic hemodynamics were measured in six normal dogs and in 18 dogs that had the bile ducts ligated for a period of 8 weeks. In the bile duct‐ligated dogs, there was a decrease in arterial pressure (110 ± 4 mm Hg vs. normal 136 ± 6 mm Hg; p < 0.005) and peripheral vascular resistance (4.60 ± 0.38 vs. 6.28 ± 0.38 dynes‐sec‐cm−5; p < 0.02), and an increase in cardiac index (129 ± 7 vs. 98 ± 9 ml per min per kg; p < 0.05).

Makoto Hashizume, Kenzo Tanaka, Kiyoshi Inokuchi – 1 January 1983 – Morphologic alterations in the gastric microcirculation in cirrhosis were investigated following infusion of a silicone rubber compound into vessels of the excised stomach which was then cleared with methyl salicylate. In cirrhosis, arteriovenous anastomoses 15 to 50 jum in diameter were present in 5 of 10 patients; spiral arterioles were less than one‐tenth as numerous as in stomachs from noncirrhotic patients.

Alex M. Aisen, William Martel, Gary M. Glazer, Paul L. Carson – 1 January 1983 – Major advances in diagnostic imaging of the human body have been made in recent years. Positron emission tomography, a technique founded on advances in radiopharmaceuticals and radionuclide imaging apparatus, permits imaging regional metabolism, metabolite distribution, and flow. Thus far, its major applications have been in the study of the brain, and to a lesser extent, the heart; however, it is also finding a role in the study of the liver.

Roderick K. Roberts, Steven Schenker – 1 January 1983