The Influence of Vasoactive Agents on Metabolic Activity of the Liver in Cirrhosis: A Study of the Effects of Posterior Pituitary Extract, Vasopressin, and Somatostatin

Jean‐Claude Barbare, Raoul Poupon, Patrice Jaillon, Philippe Bories, Michele Aussanaire, François Darnis, Henri Michel, Georges Cheymol – 1 January 1984 – We studied the influence of posterior pituitary extract, vasopressin, and somatostatin on hepatic elimination function. Hepatic clearance and its two biological determinants, hepatic blood flow and metabolic activity (clearance Vmax/Km), were determined from hepatic indocyanine green elimination at steady‐state in cirrhotic patients.

Human Liver Transplantation: Analysis of Data on 540 Patients from Four Centers

Bruce F. Scharschmidt – 1 January 1984 – The results of liver transplantation in a total of 540 patients from four centers in the United States and Western Europe have been collated. Twenty‐five per cent of all transplants were performed for neoplastic disease. One– and 3–year survivals for this group were approximately 26 and 12% overall, and survival differed little for patients transplanted before and after January 1, 1980. Among the 44% of patients transplanted for endstage cirrhosis, 3–year survival was lowest for patients with alcoholic cirrhosis (20%).

Ultrastructural Studies of Fibroblasts Transfected with Hepatitis B Virus DNA

Naoto Aoki, Michael A. Gerber, Swan N. Thung, Mei‐Ling Chen, Judith K. Christman, Peter M. Price, Christos S. Flordellis, George Acs – 1 January 1984 – Cultured 3T3 mouse fibroblasts transfected with cloned hepatitis B virus genome and DNA coding for methotrexate‐resistant dihydrofolate reductase, produce and secrete significant amounts of hepatitis B surface antigen (HBsAg).

Hepatic Free Fatty Acids in Alcoholic Liver Disease and Morbid Obesity

Peter G. Mavrelis, Helmut V. Ammon, John J. Gleysteen, Richard A. Komorowski, Ursula K. Charaf – 1 January 1983 – Alcoholic liver disease is characterized by the accumulation of fat and inflammatory changes in the liver. Because free fatty acids, the precursors of triglycerides, can damage biological membranes, accumulation of free fatty acids in the liver might be in part responsible for the functional and morphological changes seen in alcoholic liver disease.

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