Frailty and Sarcopenia in Acute‐on‐Chronic Liver Failure

Lorena Puchades Renau, Julia Herreras López, Maria Àngels Cebrià i Iranzo, Natalia Cezón Serrano, Tommaso Di Maira, Marina Berenguer – 3 May 2021 – In patients with cirrhosis, sarcopenia is a critical reduction in skeletal muscle mass and frailty represents a status of global physical dysfunction caused by under nutrition, muscle wasting, and functional impairment. Both are prevalent conditions in liver transplant candidates and have shown to be independent predictors of adverse outcome.

Point‐of‐Care Assessment of DCD Livers During Normothermic Machine Perfusion in a Nonhuman Primate Model

Samuel J. Kesseli, Jared N. Gloria, Nader Abraham, Samantha E. Halpern, Greta N. Cywinska, Min Zhang, Dimitrios Moris, Robin Schmitz, Brian I. Shaw, Zachary W. Fitch, Mingqing Song, Cynthia D. Guy, Mathew G Hartwig, Stuart Knechtle, Andrew S. Barbas – 3 May 2021 – Normothermic machine perfusion (NMP) provides clinicians an opportunity to assess marginal livers before transplantation. However, objective criteria and point‐of‐care (POC) biomarkers to predict risk and guide decision making are lacking.

DNA Methylation Markers for Detection of Cholangiocarcinoma: Discovery, Validation, and Clinical Testing in Biliary Brushings and Plasma

Ju Dong Yang, Hassan Ghoz, Mohammed M. Aboelsoud, William R. Taylor, Tracy C. Yab, Calise K. Berger, Xiaoming Cao, Patrick H. Foote, Nasra H. Giama, Emily G. Barr Fritcher, Douglas W. Mahoney, Catherine D. Moser, Thomas C. Smyrk, Benjamin R. Kipp, Gregory J. Gores, Lewis R. Roberts, John B. Kisiel – 2 May 2021 – Cholangiocarcinoma (CCA) has poor prognosis due to late‐stage, symptomatic presentation. Altered DNA methylation markers may improve diagnosis of CCA.

Postdiagnosis Aspirin Use Associated With Decreased Biliary Tract Cancer–Specific Mortality in a Large Nationwide Cohort

Shu‐Fen Liao, Jill Koshiol, Yi‐Hsiang Huang, Sarah S. Jackson, Yu‐Han Huang, Chi Chan, Claire Huang, Po‐Chun Liu, Yen‐Ju Chen, Rebecca J. Hsieh, Ching‐Po Huang, Sheng‐Nan Lu, Chien‐Jen Chen, Chen‐Yang Shen, Mei‐Hsuan Lee – 2 May 2021

Key Elements on the Pathway to HCV Elimination: Lessons Learned From the AASLD HCV Special Interest Group 2020

Jordan J. Feld, John W. Ward – 2 May 2021 – With a decade left to reach the ambitious goals for viral hepatitis elimination set out by the World Health Organization, many challenges remain. Despite the remarkable improvements in therapy for hepatitis C virus (HCV) infection, most people living with the infection remain undiagnosed, and only a fraction have received curative therapy.

What Survivorship Means to Liver Transplant Recipients: Qualitative Groundwork for a Survivorship Conceptual Model

Sarah R. Lieber, Hannah P. Kim, Luke Baldelli, Rebekah Nash, Randall Teal, Gabrielle Magee, Marci M. Loiselle, Chirag S. Desai, Simon C. Lee, Amit G. Singal, Jorge A. Marrero, A. Sidney Barritt, Donna M. Evon – 2 May 2021 – Survivorship is a well‐established concept in the cancer care continuum with a focus on disease recurrence, quality of life, and the minimization of competing risks for mortality; however, survivorship has not been well studied in liver transplantation (LT).

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