Cooperation Between the NRF2 Pathway and Oncogenic β‐catenin During HCC Tumorigenesis

Mathilde Savall, Nadia Senni, Isabelle Lagoutte, Pierre Sohier, Renaud Dentin, Beatrice Romagnolo, Christine Perret, Pascale Bossard – 3 June 2021 – CTNNB1 (catenin beta 1)–mutated hepatocellular carcinomas (HCCs) account for a large proportion of human HCCs. They display high levels of respiratory chain activity. As metabolism and redox balance are closely linked, tumor cells must maintain their redox status during these metabolic alterations. We investigated the redox balance of these HCCs and the feasibility of targeting this balance as an avenue for targeted therapy.

Acute Liver Failure Etiology Is an Independent Predictor of Waitlist Outcome but Not Posttransplantation Survival in a National Cohort

Natalie Z. Wong, K. Rajender Reddy, Therese Bittermann – 2 June 2021 – The impact of acute liver failure (ALF) etiology on waitlist (WL) and posttransplantation outcomes, independent of severity of illness, is incompletely characterized. All adults (n = 1691) listed for primary liver transplantation (LT) between 2002 and 2019 with ALF due to acetaminophen toxicity (APAP), drug‐induced liver injury (DILI), autoimmune hepatitis (AIH), and hepatitis B virus (HBV) were identified in the United Network for Organ Sharing database.

Activated CD4+ T Cells and Highly Differentiated Alloreactive CD4+ T Cells Distinguish Operationally Tolerant Liver Transplantation Recipients

Aafke A. Duizendstra, Robert J. Knegt, Shanta Mancham, Mariska Klepper, Dave L. Roelen, Simone H. Brand‐Schaaf, Patrick P. Boor, Michail Doukas, Robert A. Man, Dave Sprengers, Maikel P. Peppelenbosch, Michiel G. H. Betjes, Jaap Kwekkeboom, Nicolle H. R. Litjens – 2 June 2021 – Spontaneous operational tolerance to the allograft develops in a proportion of liver transplantation (LT) recipients weaned off immunosuppressive (IS) drugs.

LiverLearning®: 2021 Webinar: Natural History of NAFLD/NASH in Children: Knowledge, Gaps and Interventions

The gap in natural history data for NAFLD/NASH in children is large, but there have been some significant advances made in the past couple of years. This webinar aims to increase awareness, enhance knowledge and improve health of children with this disorder.Shikha Sundaram Shikha S. Sundaram, MD, FAASLD, is an associate professor of Pediatrics at Children’s Hospital Colorado and the University of Colorado School of Medicine.

Hepatic Adenosine Triphosphate Reduction Through the Short‐Chain Fatty Acids–Peroxisome Proliferator‐Activated Receptor γ–Uncoupling Protein 2 Axis Alleviates Immune‐Mediated Acute Hepatitis in Inulin‐Supplemented Mice

Akihiro Yamaguchi, Toshiaki Teratani, Po‐sung Chu, Takahiro Suzuki, Nobuhito Taniki, Yohei Mikami, Shunsuke Shiba, Rei Morikawa, Takeru Amiya, Ryo Aoki, Takanori Kanai, Nobuhiro Nakamoto – 1 June 2021 – How liver tolerance is disrupted in immune‐mediated liver injury is currently unclear. There is also insufficient information available regarding susceptibility, precipitation, escalation, and perpetuation of autoimmune hepatitis.

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