Bile Salt and FGF19 Signaling in the Early Phase of Human Liver Regeneration

Kiran V.K. Koelfat, Kim M.C. Mierlo, Toine M. Lodewick, Johanne G. Bloemen, Gregory Kroft, Iakovos Amygdalos, Ulf P. Neumann, Cornelis H.C. Dejong, Peter L.M. Jansen, Steven W.M. Olde Damink, Frank G. Schaap – 4 May 2021 – The involvement of bile salt–fibroblast growth factor 19 (FGF19) signaling in human liver regeneration (LR) is not well studied. Therefore, we studied aspects of bile salt–FGF19 signaling shortly after liver resection in patients.

Hepatocellular Carcinoma Screening Process Failures in Patients with Cirrhosis

Patrick Marquardt, Po‐Hong Liu, Joshua Immergluck, Jocelyn Olivares, Ana Arroyo, Nicole E. Rich, Neehar D. Parikh, Adam C. Yopp, Amit G. Singal – 3 May 2021 – Professional society guidelines recommend semiannual screening for hepatocellular carcinoma (HCC) in patients with cirrhosis; however, studies suggest underuse of screening in clinical practice. Our study’s aim was to characterize reasons for HCC screening underuse among patients with cirrhosis. We conducted a retrospective cohort study of patients with cirrhosis diagnosed with HCC in two large health systems from 2011 to 2019.

Frailty and Sarcopenia in Acute‐on‐Chronic Liver Failure

Lorena Puchades Renau, Julia Herreras López, Maria Àngels Cebrià i Iranzo, Natalia Cezón Serrano, Tommaso Di Maira, Marina Berenguer – 3 May 2021 – In patients with cirrhosis, sarcopenia is a critical reduction in skeletal muscle mass and frailty represents a status of global physical dysfunction caused by under nutrition, muscle wasting, and functional impairment. Both are prevalent conditions in liver transplant candidates and have shown to be independent predictors of adverse outcome.

Point‐of‐Care Assessment of DCD Livers During Normothermic Machine Perfusion in a Nonhuman Primate Model

Samuel J. Kesseli, Jared N. Gloria, Nader Abraham, Samantha E. Halpern, Greta N. Cywinska, Min Zhang, Dimitrios Moris, Robin Schmitz, Brian I. Shaw, Zachary W. Fitch, Mingqing Song, Cynthia D. Guy, Mathew G Hartwig, Stuart Knechtle, Andrew S. Barbas – 3 May 2021 – Normothermic machine perfusion (NMP) provides clinicians an opportunity to assess marginal livers before transplantation. However, objective criteria and point‐of‐care (POC) biomarkers to predict risk and guide decision making are lacking.

DNA Methylation Markers for Detection of Cholangiocarcinoma: Discovery, Validation, and Clinical Testing in Biliary Brushings and Plasma

Ju Dong Yang, Hassan Ghoz, Mohammed M. Aboelsoud, William R. Taylor, Tracy C. Yab, Calise K. Berger, Xiaoming Cao, Patrick H. Foote, Nasra H. Giama, Emily G. Barr Fritcher, Douglas W. Mahoney, Catherine D. Moser, Thomas C. Smyrk, Benjamin R. Kipp, Gregory J. Gores, Lewis R. Roberts, John B. Kisiel – 2 May 2021 – Cholangiocarcinoma (CCA) has poor prognosis due to late‐stage, symptomatic presentation. Altered DNA methylation markers may improve diagnosis of CCA.

Postdiagnosis Aspirin Use Associated With Decreased Biliary Tract Cancer–Specific Mortality in a Large Nationwide Cohort

Shu‐Fen Liao, Jill Koshiol, Yi‐Hsiang Huang, Sarah S. Jackson, Yu‐Han Huang, Chi Chan, Claire Huang, Po‐Chun Liu, Yen‐Ju Chen, Rebecca J. Hsieh, Ching‐Po Huang, Sheng‐Nan Lu, Chien‐Jen Chen, Chen‐Yang Shen, Mei‐Hsuan Lee – 2 May 2021

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