Allan G. Redeker, M.D. (1924‐2021)
Tse‐Ling Fong, Jay H. Hoofnagle – 21 May 2021
Myeloid Endoplasmic Reticulum Resident Chaperone GP96 Facilitates Inflammation and Steatosis in Alcohol‐Associated Liver Disease
Anuradha Ratna, Arlene Lim, Zihai Li, Josepmaria Argemi, Ramon Bataller, Gabriela Chiosis, Pranoti Mandrekar – 21 May 2021 – Cellular stress–mediated chaperones are linked to liver macrophage activation and inflammation in alcohol‐associated liver disease (ALD). In this study, we investigate the role of endoplasmic reticulum (ER) resident stress chaperone GP96/HSP90B1/GRP94, paralog of the HSP90 family, in ALD pathogenesis. We hypothesize that ER resident chaperone, heat shock protein GP96, plays a crucial role in alcohol‐associated liver inflammation and contributes to liver injury.
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Abdul Rahman Hakeem, Mettu Srinivas Reddy, Mohamed Rela – 21 May 2021
How to Select Elderly Patients for Living Donor Liver Transplantation With Acceptable Outcomes
Kenei Furukawa, Koichiro Haruki, Tomohiko Taniai, Hironari Kawai, Toru Ikegami – 21 May 2021
Letter to the Editor: Is Male Sex Associated With Increased Liver‐Related Mortality in Primary Biliary Cholangitis and Cirrhosis?
Li‐Yang Sun, Jia‐Yu Hu, Lei Liang, Xiang‐Min Tong, Dong‐Sheng Huang, Tian Yang – 21 May 2021
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Binu V. John, Yangyang Deng, Paul Martin, Cynthia Levy, Tamar H. Taddei, David E. Kaplan, Bassam Dahman – 21 May 2021
Type 2 Autoimmune Hepatitis and Nonadherence to Medication Correlate With Premature Birth and Risk of Postpartum Flare
Kathryn Olsen, James Hodson, Vincenzo Ronca, Amber G. Bozward, Jennifer Hayden, Grace Wootton, Matthew Armstrong, David H. Adams, Omar El‐Sherif, James Ferguson, Ellen Knox, Tracey Johnston, Fiona Thompson, Ye Htun Oo – 20 May 2021 – Autoimmune hepatitis (AIH) is an immune‐mediated chronic liver disease that affects all ages, including women of childbearing age. Optimal management during pregnancy is poorly defined.
Type 2 Autoimmune Hepatitis and Nonadherence to Medication Correlate With Premature Birth and Risk of Postpartum Flare
Kathryn Olsen, James Hodson, Vincenzo Ronca, Amber G. Bozward, Jennifer Hayden, Grace Wootton, Matthew Armstrong, David H. Adams, Omar El‐Sherif, James Ferguson, Ellen Knox, Tracey Johnston, Fiona Thompson, Ye Htun Oo – 20 May 2021 – Autoimmune hepatitis (AIH) is an immune‐mediated chronic liver disease that affects all ages, including women of childbearing age. Optimal management during pregnancy is poorly defined.
Cannabinoid Use Among Liver Transplant Recipients
Kathleen Yan, Lisa Forman – 20 May 2021 – The effect of cannabinoids on liver transplant outcomes is an area of active research. We aimed to investigate marijuana (MJ) and cannabidiol (CBD) use among liver transplant recipients at the University of Colorado Hospital (UCH), specifically prevalence, habits, and predictors of use. Liver transplant recipients followed at UCH with valid email addresses were sent an informed consent postcard and survey invitation. This exploratory survey was conducted using REDCap. IBM SPSS Statistics software was used for statistical analysis.
Hepatic Encephalopathy and Liver Transplantation: The Past, Present, and Future Toward Equitable Access
Chathur Acharya, Jasmohan S. Bajaj – 20 May 2021 – Cirrhosis is a debilitating chronic disease with high morbidity and mortality, with the only real cure being liver transplantation (LT). Currently, we allocate organs for transplantation based on the Model for End‐Stage Liver Disease–Sodium (MELD‐Na) score that does not account for hepatic encephalopathy (HE). HE affects patients, families, and the health care system because of high rates of recurrence and major readmission burden. Moreover, HE casts a long shadow even after LT.