Isabel M. A. Brüggenwirth, Otto B. Leeuwen, Robert J. Porte, Paulo N. Martins – 7 May 2021 – The transplant community continues to be challenged by the disparity between the need for liver transplantation and the shortage of suitable donor organs. At the same time, the number of unused donor livers continues to increase, most likely attributed to the worsening quality of these organs. To date, there is no reliable marker of liver graft viability that can predict good posttransplant outcomes.

Peter E. Frasco, Bashar Aqel, Jeremy M. Alvord, Karl A. Poterack, Isabel Bauer, Amit K. Mathur – 7 May 2021 – Statin therapy may reduce the risk of venous thromboembolism (VTE), which may impact solid organ transplant outcomes. We evaluated the incidence of VTE and other complications after liver transplantation stratified by hyperlipidemia status and statin use using a retrospective cohort study approach. We reviewed all primary orthotopic liver transplantation (OLT) records from January 2014 to December 2019 from our center. Intraoperative deaths were excluded.

Arun Jose, Shimul A. Shah, Nadeem Anwar, Courtney R. Jones, Kenneth E. Sherman, Jean M. Elwing – 7 May 2021 – Portopulmonary hypertension (POPH) is a pulmonary vascular disease associated with significant morbidity and mortality in those with liver disease, conferring a higher mortality in patients awaiting liver transplantation (LT).

Victor Dong, Mitra K. Nadim, Constantine J. Karvellas – 7 May 2021 – Acute kidney injury (AKI) is a common condition following liver transplantation (LT). It negatively impacts patient outcomes by increasing the chances of developing chronic kidney disease and reducing graft and patient survival rates. Multiple definitions of AKI have been proposed and used throughout the years, with the International Club of Ascites definition being the most widely now used for patients with cirrhosis.

Fanta Barrow, Saad Khan, Haiguang Wang, Xavier S. Revelo – 6 May 2021 – NAFLD is one of the leading causes of abnormal liver function worldwide. NAFLD refers to a group of liver conditions ranging from nonalcoholic fatty liver to NASH, which involves inflammation, hepatocellular damage, and fibrosis. Triggering of inflammation in NASH is a key event in the progression of the disease, and identifying the factors that initiate or dysregulate this process is needed to develop strategies for its prevention or treatment.

Terry Cheuk‐Fung Yip, Vincent Wai‐Sun Wong, Grace Chung‐Yan Lui, Viola Chi‐Ying Chow, Yee‐Kit Tse, Vicki Wing‐Ki Hui, Lilian Yan Liang, Henry Lik‐Yuen Chan, David Shu‐Cheong Hui, Grace Lai‐Hung Wong – 6 May 2021

Ravi Jhaveri, Lynn M. Yee, Swati Antala, Margaret Murphy, William A. Grobman, Seema K. Shah – 6 May 2021

Binu V. John, Kaley Schwartz, Cynthia Levy, Bassam Dahman, Yangyang Deng, Paul Martin, Tamar H. Taddei, David E. Kaplan – 5 May 2021 – Obeticholic acid (OCA) is approved for the treatment of patients with primary biliary cholangitis (PBC) who are partial responders or intolerant to ursodeoxycholic acid. Reports of serious liver injury have raised concerns about its safety in cirrhosis. We investigated the effects of treatment with OCA on hepatic decompensation and liver‐related mortality or transplantation in a cohort with compensated PBC cirrhosis.

Catherine A Chapin, Sarah A Taylor, Padmini Malladi, Katie Neighbors, Hector Melin‐Aldana, Portia A Kreiger, Nina Bowsher, Matthew J Schipma, Kathleen M Loomes, Edward M Behrens, Estella M Alonso – 5 May 2021 – Many patients with indeterminate pediatric acute liver failure (PALF) have evidence of T‐cell driven immune injury; however, the precise inflammatory pathways are not well defined. We have characterized the hepatic cytokine and transcriptional signatures of patients with PALF.

Alessandra Gentilini, Giulia Lori, Alessandra Caligiuri, Chiara Raggi, Giovanni Di Maira, Mirella Pastore, Benedetta Piombanti, Tiziano Lottini, Annarosa Arcangeli, Stefania Madiai, Nadia Navari, Jesus M. Banales, Sabina Di Matteo, Domenico Alvaro, Lea Duwe, Jesper B. Andersen, Alessandro Tubita, Ignazia Tusa, Luca Di Tommaso, Claudia Campani, Elisabetta Rovida, Fabio Marra – 5 May 2021