Myeloid Endoplasmic Reticulum Resident Chaperone GP96 Facilitates Inflammation and Steatosis in Alcohol‐Associated Liver Disease

Anuradha Ratna, Arlene Lim, Zihai Li, Josepmaria Argemi, Ramon Bataller, Gabriela Chiosis, Pranoti Mandrekar – 21 May 2021 – Cellular stress–mediated chaperones are linked to liver macrophage activation and inflammation in alcohol‐associated liver disease (ALD). In this study, we investigate the role of endoplasmic reticulum (ER) resident stress chaperone GP96/HSP90B1/GRP94, paralog of the HSP90 family, in ALD pathogenesis. We hypothesize that ER resident chaperone, heat shock protein GP96, plays a crucial role in alcohol‐associated liver inflammation and contributes to liver injury.

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Binu V. John, Yangyang Deng, Paul Martin, Cynthia Levy, Tamar H. Taddei, David E. Kaplan, Bassam Dahman – 21 May 2021

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