Acute Liver Failure Etiology Is an Independent Predictor of Waitlist Outcome but Not Posttransplantation Survival in a National Cohort

Natalie Z. Wong, K. Rajender Reddy, Therese Bittermann – 2 June 2021 – The impact of acute liver failure (ALF) etiology on waitlist (WL) and posttransplantation outcomes, independent of severity of illness, is incompletely characterized. All adults (n = 1691) listed for primary liver transplantation (LT) between 2002 and 2019 with ALF due to acetaminophen toxicity (APAP), drug‐induced liver injury (DILI), autoimmune hepatitis (AIH), and hepatitis B virus (HBV) were identified in the United Network for Organ Sharing database.

Activated CD4+ T Cells and Highly Differentiated Alloreactive CD4+ T Cells Distinguish Operationally Tolerant Liver Transplantation Recipients

Aafke A. Duizendstra, Robert J. Knegt, Shanta Mancham, Mariska Klepper, Dave L. Roelen, Simone H. Brand‐Schaaf, Patrick P. Boor, Michail Doukas, Robert A. Man, Dave Sprengers, Maikel P. Peppelenbosch, Michiel G. H. Betjes, Jaap Kwekkeboom, Nicolle H. R. Litjens – 2 June 2021 – Spontaneous operational tolerance to the allograft develops in a proportion of liver transplantation (LT) recipients weaned off immunosuppressive (IS) drugs.

LiverLearning®: 2021 Webinar: Natural History of NAFLD/NASH in Children: Knowledge, Gaps and Interventions

The gap in natural history data for NAFLD/NASH in children is large, but there have been some significant advances made in the past couple of years. This webinar aims to increase awareness, enhance knowledge and improve health of children with this disorder.Shikha Sundaram Shikha S. Sundaram, MD, FAASLD, is an associate professor of Pediatrics at Children’s Hospital Colorado and the University of Colorado School of Medicine.

Hepatic Adenosine Triphosphate Reduction Through the Short‐Chain Fatty Acids–Peroxisome Proliferator‐Activated Receptor γ–Uncoupling Protein 2 Axis Alleviates Immune‐Mediated Acute Hepatitis in Inulin‐Supplemented Mice

Akihiro Yamaguchi, Toshiaki Teratani, Po‐sung Chu, Takahiro Suzuki, Nobuhito Taniki, Yohei Mikami, Shunsuke Shiba, Rei Morikawa, Takeru Amiya, Ryo Aoki, Takanori Kanai, Nobuhiro Nakamoto – 1 June 2021 – How liver tolerance is disrupted in immune‐mediated liver injury is currently unclear. There is also insufficient information available regarding susceptibility, precipitation, escalation, and perpetuation of autoimmune hepatitis.

Equitable Access to Liver Transplant: Bridging the Gaps in the Social Determinants of Health

Russell Rosenblatt, Hannah Lee, AnnMarie Liapakis, Keri E. Lunsford, Andrew Scott, Pratima Sharma, Julius Wilder – 31 May 2021 – The COVID‐19 pandemic and social justice movement have highlighted the impact of social determinants of health (SDOH) and structural racism in the United States on both access to care and patient outcomes. With the evaluation for liver transplantation being a highly subjective process, there are multiple ways for SDOH to place vulnerable patients at a disadvantage.

Equitable Access to Liver Transplant: Bridging the Gaps in the Social Determinants of Health

Russell Rosenblatt, Hannah Lee, AnnMarie Liapakis, Keri E. Lunsford, Andrew Scott, Pratima Sharma, Julius Wilder – 31 May 2021 – The COVID‐19 pandemic and social justice movement have highlighted the impact of social determinants of health (SDOH) and structural racism in the United States on both access to care and patient outcomes. With the evaluation for liver transplantation being a highly subjective process, there are multiple ways for SDOH to place vulnerable patients at a disadvantage.

Liver Transplantation in Children with Urea Cycle Disorders: The Importance of Minimizing Waiting Time

Ioannis A. Ziogas, W. Kelly Wu, Lea K. Matsuoka, Anita K. Pai, Einar T. Hafberg, Lynette A. Gillis, Thomas M. Morgan, Sophoclis P. Alexopoulos – 30 May 2021 – Liver transplantation (LT) for children with urea cycle disorders (UCDs) is capable of correcting the enzymatic defect and preventing progressive neurologic injury. We describe the characteristics and outcomes of pediatric LT recipients with UCDs. We identified all pediatric (<18 years) LT candidates with UCDs in the United Network for Organ Sharing (UNOS) database (February 2002 to September 2020).

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