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Jasmohan S. Bajaj, Guadalupe Garcia‐Tsao, Patrick S. Kamath, Jacqueline G. O’Leary, K. Rajender Reddy, Florence Wong – 9 June 2021

Obeticholic Acid Decreases Intestinal Content of Enterococcus in Rats With Cirrhosis and Ascites

Kathleen Yan, Adelina Hung, Caitlin Parmer, Hui Yang, Dhanpat Jain, Bentley Lim, Andrew L. Goodman, Guadalupe Garcia‐Tsao – 9 June 2021 – The intestinal microbiome and bacterial translocation (BT), the passage of microorganisms from the gut lumen to mesenteric lymph nodes and other extra‐intestinal sites, are main mechanisms implicated in liver injury and further decompensation in patients with cirrhosis. We hypothesized that obeticholic acid (OCA), a semisynthetic bile acid, would change the microbiome composition and reduce bacterial translocation in experimental cirrhosis.

The Level of Alcohol Consumption in the Prior Year Does Not Impact Clinical Outcomes in Patients With Alcohol‐Associated Hepatitis

Jessica A. Musto, Jens Eickhoff, Meritxell Ventura‐Cots, Juan G. Abraldes, Francisco Bosques‐Padilla, Elizabeth C. Verna, Robert S. Brown, Victor Vargas, Jose Altamirano, Juan Caballería, Debbie Shawcross, Alexandre Louvet, Philippe Mathurin, Guadalupe Garcia‐Tsao, Bernd Schnabl, Ramon Bataller, Michael R. Lucey – 9 June 2021 – The 10‐item Alcohol Use Disorders Identification Test (AUDIT‐10) and its shorter form, AUDIT‐Consumption (AUDIT‐C), are questionnaires used to characterize severity of drinking.

Immune Activation Induces Telomeric DNA Damage and Promotes Short‐Lived Effector T Cell Differentiation in Chronic HCV Infection

Lam Nhat Nguyen, Lam Ngoc Thao Nguyen, Juan Zhao, Madison Schank, Xindi Dang, Dechao Cao, Sushant Khanal, Bal Krishna Chand Thakuri, Jinyu Zhang, Zeyuan Lu, Xiao Y. Wu, Mohamed El Gazzar, Shunbin Ning, Ling Wang, Jonathan P. Moorman, Zhi Q. Yao – 9 June 2021

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