Angeliki Katsarou, Konstantinos Gkouvatsos, Carine Fillebeen, Kostas Pantopoulos – 15 July 2021 – Hepcidin is a liver‐derived peptide hormone that limits iron egress from tissues to the bloodstream. It operates by binding to the iron exporter ferroportin, which blocks iron transport and tags ferroportin for degradation. Genetic hepcidin inactivation leads to hereditary hemochromatosis, a disease of iron overload. We used wild‐type and Hjv‐/‐ mice, a model of hemochromatosis, to examine the expression of ferroportin and other proteins of iron metabolism in hepcidin target tissues.

Giuseppe Cullaro, Pratima Sharma, Jennifer Jo, Jasmine Rassiwala, Lisa B. VanWagner, Randi Wong, Jennifer C. Lai, John Magee, Aaron Schluger, Pranab Barman, Yuval A. Patel, Kara Walter, Scott W. Biggins, Elizabeth C. Verna – 14 July 2021 – We aimed to understand the contemporary changes in the characteristics and the determinants of outcomes among simultaneous liver‐kidney transplantation (SLKT) recipients at 6 liver transplantation centers in the United States. We retrospectively enrolled SLKT recipients between 2002 and 2017 in the US Multicenter SLKT Consortium.

Mark Shapses, Lin Tang, Austin Layne, Andrea Beri, Yaron Rotman – 14 July 2021 – Fatty liver (FL) is associated with altered activity of hepatic drug‐metabolizing enzymes, but the clinical significance is unknown. Many anesthetic agents are metabolized in the liver. We aimed to determine whether FL impacts recovery from anesthesia as a surrogate for altered drug metabolism. This was a single‐center, retrospective, case‐control study of all adults who underwent anesthesia and concurrent abdominal imaging (n = 2,021) in a hospital setting.

Nadim Mahmud, David S. Goldberg, Therese Bittermann – 14 July 2021 – With advances in computing and information technology, large health care research databases are becoming increasingly accessible to investigators across the world. These rich, population‐level data sources can serve many purposes, such as to generate “real‐world evidence,” to enhance disease phenotyping, or to identify unmet clinical needs, among others.

13 July 2021

Ankur Jindal – 13 July 2021

Lukas Otero Sanchez, Eleni Karakike, Christophe Moreno, Eric Trépo, Thierry Gustot – 13 July 2021

There is increasing interest to integrate palliative care (PC) within routine practice of decompensated cirrhosis to enhance and inform clinical care. It has shown to improve patient- provider communication, provider awareness of symptoms, tailored symptom management enhance quality of life, ultimately with a better end of life care. There is minimal knowledge on what key elements of PC can inform care, particularly if advance care planning (ACP) has a role to play within Transplant Evaluation.Arpan A. Patel Aran A.

Mark S. Sulkowski, Juhi S. Moon, Kenneth E. Sherman, Giuseppe Morelli, Jama M. Darling, Andrew J. Muir, Mandana Khalili, Dawn A. Fishbein, Federico Hinestrosa, Mitchell L. Shiffman, Adrian Di Bisceglie, K. Rajender Reddy, Brian Pearlman, Anna S. Lok, Michael W. Fried, Paul W. Stewart, Joy Peter, Summer Wadsworth, Scott Kixmiller, Anquenette Sloan, Monika Vainorius, Patrick M. Horne, Larry Michael, Meichen Dong, Donna M. Evon, Jodi B. Segal, David R. Nelson, the PRIORITIZE Study Team – 12 July 2021

Bess M. Miller, Isaac M. Oderberg, Wolfram Goessling – 12 July 2021 – The liver is innervated by autonomic and sensory fibers of the sympathetic and parasympathetic nervous systems that regulate liver function, regeneration, and disease. Although the importance of the hepatic nervous system in maintaining and restoring liver homeostasis is increasingly appreciated, much remains unknown about the specific mechanisms by which hepatic nerves both influence and are influenced by liver diseases.