Medicaid Expansion Association With End‐Stage Liver Disease Mortality Depends on Leniency of Medicaid Hepatitis C Virus Coverage

Nabeel A. Wahid, Jihui Lee, Alyson Kaplan, Brett E. Fortune, Monika M. Safford, Robert S. Brown, Russell Rosenblatt – 11 June 2021 – The Affordable Care Act expanded Medicaid around the same time that direct‐acting antivirals became widely available for the treatment of hepatitis C virus (HCV). However, there is significant variation in Medicaid HCV treatment eligibility criteria between states. We explored the combined effects of Medicaid expansion and leniency of HCV coverage under Medicaid on liver outcomes.

Inclusive Quantification Assay of Serum Des‐γ‐Carboxyprothrombin Proteoforms for Hepatocellular Carcinoma Surveillance by Targeted Mass Spectrometry

Jihyeon Lee, Young‐Suk Lim, Jeong‐Hoon Lee, Geum‐Youn Gwak, Misol Do, Injoon Yeo, Dongyoon Shin, Dohyun Han, Taesung Park, Youngsoo Kim – 11 June 2021 – Hepatocellular carcinoma (HCC) is a malignant cancer with one of the highest mortality rates. Des‐γ‐carboxyprothrombin (DCP) is an HCC serologic surveillance marker that can complement the low sensitivity of alpha‐fetoprotein (AFP). DCP exists in the blood as a mixture of proteoforms from an impaired carboxylation process at glutamic acid (Glu) residues within the N‐terminal domain.

Interleukin‐10 and Transforming Growth Factor‐β Cytokines Decrease Immune Activation During Normothermic Ex Vivo Machine Perfusion of the Rat Liver

Kristin N. Carlson, Juliana Pavan‐Guimaraes, Joshua C. Verhagen, Peter Chlebeck, Bret Verhoven, Heather Jennings, Feridoon Najmabadi, Yongjun Liu, William Burlingham, Christian M. Capitini, David P. Al‐Adra – 11 June 2021 – Normothermic ex vivo liver perfusion (NEVLP) is a novel system for organ preservation that may improve over static cold storage clinically and offers the chance for graft modification prior to transplantation.

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