Incidence and prediction of HBsAg seroclearance in a prospective multi‐ethnic HBeAg‐negative chronic hepatitis B cohort

Norah A. Terrault, Abdus S. Wahed, Jordan J. Feld, Stewart L. Cooper, Mark G. Ghany, Mauricio Lisker‐Melman, Robert Perrillo, Richard K. Sterling, Mandana Khalili, Raymond T. Chung, Philip Rosenthal, Robert J. Fontana, Arif Sarowar, Daryl T. Y. Lau, Junyao Wang, Anna S. Lok, Harry L. A. Janssen – 6 November 2021

Integrating Specialist Palliative Care in the Liver Transplantation Evaluation Process: A Qualitative Analysis of Hepatologist and Palliative Care Provider Views

Myrick C. Shinall, Kemberlee Bonnet, David Schlundt, Manisha Verma – 6 November 2021 – Patients undergoing evaluation for liver transplantation face heavy burdens of symptoms, health care use, and mortality. In other similarly ill populations, specialist palliative care has been shown to benefit patients, but specialist palliative care is infrequently used for liver transplantation patients. This project aims to describe the potential benefits of and barriers to specialist palliative care integration in the liver transplantation process.

Melatonin receptor 1A, but not 1B, knockout decreases biliary damage and liver fibrosis during cholestatic liver injury

Nan Wu, Guido Carpino, Ludovica Ceci, Leonardo Baiocchi, Heather Francis, Lindsey Kennedy, Tianhao Zhou, Lixian Chen, Keisaku Sato, Konstantina Kyritsi, Vik Meadows, Burcin Ekser, Antonio Franchitto, Romina Mancinelli, Paolo Onori, Eugenio Gaudio, Shannon Glaser, Gianfranco Alpini – 6 November 2021

Molecular Imaging of Tumor Microenvironment to Assess the Effects of Locoregional Treatment for Hepatocellular Carcinoma

Quan Chen, Austin Z. Chen, Guorong Jia, Jindian Li, Chuansheng Zheng, Kai Chen – 4 November 2021 – Liver cancer is one of the leading causes of cancer deaths worldwide. Among all primary liver cancers, hepatocellular carcinoma (HCC) is the most common type, representing 75%‐85% of all primary liver cancer cases. Median survival following diagnosis of HCC is approximately 6 to 20 months due to late diagnosis in its course and few effective treatment options. Interventional therapy with minimal invasiveness is recognized as a promising treatment for HCC.

Implications and Management of Cirrhosis‐Associated Immune Dysfunction Before and After Liver Transplantation

Thomas H. Tranah, Victoria T. Kronsten, Debbie L. Shawcross – 4 November 2021 – Cirrhosis‐associated immune dysfunction (CAID) describes a panacea of innate and adaptive deficits that result from the sequelae of cirrhotic portal hypertension that is similar in its manifestations regardless of etiology of chronic liver injury. CAID is associated with synchronous observations of dysregulated priming of innate immune effector cells that demonstrate a proinflammatory phenotype but are functionally impaired and unable to adequately prevent invading pathogens.

Dissecting the Balance Between Metabolic and Oncogenic Functions of Astrocyte‐Elevated Gene‐1/Metadherin

Yetirajam Rajesh, Saranya Chidambaranathan Reghupaty, Rachel G. Mendoza, Debashri Manna, Indranil Banerjee, Mark A. Subler, Korri Weldon, Zhao Lai, Shah Giashuddin, Paul B. Fisher, Arun J. Sanyal, Rebecca K. Martin, Mikhail G. Dozmorov, Jolene J. Windle, Devanand Sarkar – 4 November 2021 – Obesity is an enormous global health problem, and obesity‐induced nonalcoholic steatohepatitis (NASH) is contributing to a rising incidence and mortality for hepatocellular carcinoma (HCC).

E3 ubiquitin ligase ring finger protein 5 protects against hepatic ischemia reperfusion injury by mediating phosphoglycerate mutase family member 5 ubiquitination

Ming‐Jie Ding, Hao‐Ran Fang, Jia‐Kai Zhang, Ji‐Hua Shi, Xiao Yu, Pei‐Hao Wen, Zhi‐Hui Wang, Sheng‐Li Cao, Yi Zhang, Xiao‐Yi Shi, Hua‐Peng Zhang, Yu‐Ting He, Bing Yan, Hong‐Wei Tang, Dan‐Feng Guo, Jie Gao, Zhen Liu, Li Zhang, Shui‐Jun Zhang, Xiao‐Jing Zhang, Wen‐Zhi Guo – 3 November 2021

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