Immunomodulatory Effects of Lenvatinib Plus Anti–Programmed Cell Death Protein 1 in Mice and Rationale for Patient Enrichment in Hepatocellular Carcinoma

Laura Torrens, Carla Montironi, Marc Puigvehí, Agavni Mesropian, Jack Leslie, Philipp K. Haber, Miho Maeda, Ugne Balaseviciute, Catherine E. Willoughby, Jordi Abril‐Fornaguera, Marta Piqué‐Gili, Miguel Torres‐Martín, Judit Peix, Daniel Geh, Erik Ramon‐Gil, Behnam Saberi, Scott L. Friedman, Derek A. Mann, Daniela Sia, Josep M. Llovet – 21 June 2021

Modeling Phenotypic Heterogeneity of Glycogen Storage Disease Type 1a Liver Disease in Mice by Somatic CRISPR/CRISPR‐associated protein 9–Mediated Gene Editing

Martijn G.S. Rutten, Terry G.J. Derks, Nicolette C.A. Huijkman, Trijnie Bos, Niels J. Kloosterhuis, Kees C.W.A. Kolk, Justina C. Wolters, Mirjam H. Koster, Laura Bongiovanni, Rachel E. Thomas, Alain Bruin, Bart Sluis, Maaike H. Oosterveer – 21 June 2021

Outcomes of Kidney Allograft and Recipient Survival After Liver Transplantation by Induction Type in the United States

Samy M. Riad, Nicholas Lim, Scott Jackson, Arthur J. Matas, John Lake – 18 June 2021 – There are several choices for induction immunosuppression in kidney‐after‐liver transplantation. We used the Scientific Registry of Transplant Recipients database. We assessed all kidney‐after‐liver transplant recipients in the United States between 1/1/2000 and 7/31/2017 to study kidney graft and patient outcomes by induction type. We only included patients discharged on tacrolimus and mycophenolate with or without steroids and had a negative crossmatch before kidney engraftment.

Association of Genetic Risk Score With NAFLD in An Ethnically Diverse Cohort

Jun Wang, David V. Conti, David Bogumil, Xin Sheng, Mazen Noureddin, Lynne R. Wilkens, Loic Le Marchand, Hugo R. Rosen, Christopher A. Haiman, Veronica Wendy Setiawan – 17 June 2021 – Most genetic studies of nonalcoholic fatty liver disease (NAFLD) have been conducted in Whites. In this large and ethnically diverse cohort, we assessed the transportability of previously identified genetic variants for NAFLD, built a genetic risk score (GRS), and examined its association with NAFLD risk in multiple ethnic groups.

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