PRO‐C3, a Serological Marker of Fibrosis, During Childhood and Correlations With Fibrosis in Pediatric NAFLD

Catherine C. Cohen, Eduardo Castillo‐Leon, Alton B. Farris, Shelley A. Caltharp, Rebecca L. Cleeton, Elizabeth M. Sinclair, Diane E. Shevell, Morten A. Karsdal, Mette Juul Fisker Nielsen, Diana J. Leeming, Miriam B. Vos – 7 July 2021 – Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease in children and may lead to cirrhosis requiring liver transplant. Thus, prompt diagnosis of advanced fibrosis is essential.

Dietary Risks for Liver Mortality in NAFLD: Global Burden of Disease Data

James M. Paik, Seema Mir, Saleh A. Alqahtani, Youssef Younossi, Janus P. Ong, Zobair M. Younossi – 7 July 2021 – Nonalcoholic fatty liver disease (NAFLD) is a common but complex chronic liver disease, driven by environmental and genetic factors. We assessed metabolic and dietary risk factor associations with NAFLD liver mortality using the Global Burden of Disease (GBD) 2017 data. NAFLD liver deaths were calculated (per 100,000) as age‐standardized rates (ASRs) from 195 countries and territories (21 GBD regions; 7 GBD superregions).

Automated Measurements of Body Composition in Abdominal CT Scans Using Artificial Intelligence Can Predict Mortality in Patients With Cirrhosis

Winnie Y. Zou, Binu E. Enchakalody, Peng Zhang, Nidhi Shah, Sameer D. Saini, Nicholas C. Wang, Stewart C. Wang, Grace L. Su – 6 July 2021 – Body composition measures derived from already available electronic medical records (computed tomography [CT] scans) can have significant value, but automation of measurements is needed for clinical implementation. We sought to use artificial intelligence to develop an automated method to measure body composition and test the algorithm on a clinical cohort to predict mortality.

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