Ipragliflozin Improves the Hepatic Outcomes of Patients With Diabetes with NAFLD

Hirokazu Takahashi, Takaomi Kessoku, Miwa Kawanaka, Michihiro Nonaka, Hideyuki Hyogo, Hideki Fujii, Tomoaki Nakajima, Kento Imajo, Kenichi Tanaka, Yoshihito Kubotsu, Hiroshi Isoda, Satoshi Oeda, Osamu Kurai, Masato Yoneda, Masafumi Ono, Yoichiro Kitajima, Ryo Tajiri, Ayako Takamori, Atsushi Kawaguchi, Shinichi Aishima, Masayoshi Kage, Atsushi Nakajima, Yuichiro Eguchi, Keizo Anzai – 16 June 2021 – Sodium glucose cotransporter‐2 inhibitors (SGLT2is) are now widely used to treat diabetes, but their effects on nonalcoholic fatty liver disease (NAFLD) remain to be determined.

LiverLearning®: 2021 Webinar: NASH as a Cause of Hepatocellular Carcinoma

Learn about epidemiology of NASH-HCC, differences in NASH-HCC compared to other etiologies and prevention and management of NASH-HCC. Presenters will discuss the rising burden of NASH-HCC such as its contribution to liver transplant, morbidity and mortality and cost. Along with differences in gender, presentation, prognosis and screening data, prevention, treatments such as resection versus liver transplant versus other therapies.Zobair M. Younossi Zobair M.

TNFAIP3 Interacting Protein 3 Is an Activator of Hippo‐YAP Signaling Protecting Against Hepatic Ischemia/Reperfusion Injury

Junjie Zhou, Manli Hu, Meiling He, Xiaoming Wang, Dating Sun, Yongping Huang, Xu Cheng, Jiajun Fu, Jie Cai, Tengfei Ma, Song Tian, Yufeng Hu, Fengjiao Hu, Dan Liu, Yanqi He, Lanlan Yan, Zhi‐Gang She, Xiao‐Jing Zhang, Yan‐Xiao Ji, Hui Liu, Hongliang Li, Hailong Yang, Peng Zhang – 15 June 2021

The Matrisome Genes From Hepatitis B–Related Hepatocellular Carcinoma Unveiled

Wei Chen, Romain Desert, Xiaodong Ge, Hui Han, Zhuolun Song, Sukanta Das, Dipti Athavale, Hong You, Natalia Nieto – 15 June 2021 – Chronic hepatitis B virus (HBV) infection changes the composition of the extracellular matrix (ECM) and enables the onset and progression of hepatocellular carcinoma (HCC). The ensemble of ECM proteins and associated factors is a major component of the tumor microenvironment. Our aim was to unveil the matrisome genes from HBV‐related HCC.

Extensive Health Care Utilization and Costs of an Early Liver Transplantation Program for Alcoholic Hepatitis

Gene Y. Im, Alexander S. Vogel, Sander Florman, Jonathan Nahas, Scott L. Friedman, Sarah Aqui, Laura Ford, Omar Mirza, Leona Kim‐Schluger, Thomas D. Schiano – 15 June 2021 – Early liver transplantation (LT) for severe alcoholic hepatitis (AH) is a rescue therapy for highly selected patients with favorable psychosocial profiles not responding to medical therapy. Given the expected increase of AH candidate referrals requiring complex care and comprehensive evaluations, increased workload and cost might be expected from implementing an early LT program for AH but have not been determined.

The Prognostic Utility of Intraoperative Allograft Vascular Inflow Measurements in Donation After Circulatory Death Liver Transplantation

Amit Nair, Kazunari Sasaki, Teresa Diago Uso, Giuseppe D’Amico, Bijan Eghtesad, Federico Aucejo, Choon Hyuck David Kwon, Masato Fujiki, Charles Miller, Koji Hashimoto, Cristiano Quintini – 15 June 2021 – Donation after circulatory death (DCD) liver transplantation improves deceased donor liver use and decreases waitlist burden, albeit at an increased risk of biliary complications and inferior graft survival. Employing liver vascular inflow measurements intraoperatively permits allograft prognostication.

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