A Diagnostic Test Meta‐Analysis Evaluating Imaging‐Based and Blood Biomarker–Based Assessment Tools for Fibrosis After Liver Transplantation

Cheng Han Ng, Darren Jun Hao Tan, Xiong Chang Lim, Jie Ning Yong, Nicholas Syn, Gwyneth Shook Ting Soon, Daniel Q. Huang, Jieling Xiao, Grace En Hui Lim, Wen Hui Lim, Eunice Xiang Xuan Tan, Yock Young Dan, Mazen Noureddin, Mohammad Shadab Siddiqui, Mark D. Muthiah – 28 October 2021 – Early detection of liver graft fibrosis is crucial for risk stratification to identify patients for liver biopsy and timely treatment. However, diagnostic accuracy of noninvasive tests (NITs) remains unclear.

Role of Novel Kidney Biomarkers in Patients With Cirrhosis and After Liver Transplantation

Sumeet K. Asrani, Nagasri Shankar, Briget Graca, Mitra K. Nadim, Andres Cardenas – 28 October 2021 – Acute kidney injury (AKI) and chronic kidney disease (CKD) are important drivers of morbidity and mortality in patients with cirrhosis before and after liver transplantation (LT). In this review, we examine the role of novel kidney biomarkers for early recognition of kidney injury. Studies are limited by lack of reference standards, heterogeneous definitions of outcomes and biomarker cutoffs, and inconsistent diagnostic performance.

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