Immune Activation Induces Telomeric DNA Damage and Promotes Short‐Lived Effector T Cell Differentiation in Chronic HCV Infection

Lam Nhat Nguyen, Lam Ngoc Thao Nguyen, Juan Zhao, Madison Schank, Xindi Dang, Dechao Cao, Sushant Khanal, Bal Krishna Chand Thakuri, Jinyu Zhang, Zeyuan Lu, Xiao Y. Wu, Mohamed El Gazzar, Shunbin Ning, Ling Wang, Jonathan P. Moorman, Zhi Q. Yao – 9 June 2021

Key Characteristics of Human Hepatotoxicants as a Basis for Identification and Characterization of the Causes of Liver Toxicity

Ivan Rusyn, Xabier Arzuaga, Russell C. Cattley, J. Christopher Corton, Stephen S. Ferguson, Patricio Godoy, Kathryn Z. Guyton, Neil Kaplowitz, Salman R. Khetani, Ruth A. Roberts, Robert A. Roth, Martyn T. Smith – 8 June 2021 – Hazard identification regarding adverse effects on the liver is a critical step in safety evaluations of drugs and other chemicals. Current testing paradigms for hepatotoxicity rely heavily on preclinical studies in animals and human data (epidemiology and clinical trials).

Surgical Debulking for Refractory Hyperammonemic Encephalopathy in Fibrolamellar Hepatocellular Carcinoma

Vinod Solipuram, Marina Baretti, Alexander Y. Kim, Lucy X. Chen, Jill A. Fahrner, Meral Gunay‐Aygun, Xiao P. Peng, Dylan Hardenbergh, Anna Ferguson, Paige Griffith, Yuxuan Wang, Madelena Brancati, Harish Gopalakrishna, Tomoaki Kato, Chris Shubert, Daniel Laheru, Mark Yarchoan – 8 June 2021

Transcriptomics Identify Thrombospondin‐2 as a Biomarker for NASH and Advanced Liver Fibrosis

Kazuhiro Kozumi, Takahiro Kodama, Hiroki Murai, Sadatsugu Sakane, Olivier Govaere, Simon Cockell, Daisuke Motooka, Naruyasu Kakita, Yukinori Yamada, Yasuteru Kondo, Yuki Tahata, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Yoshihiro Kamada, Ann K. Daly, Quentin M. Anstee, Tomohide Tatsumi, Eiichi Morii, Tetsuo Takehara – 8 June 2021

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