Letter to the Editor: High Mobility Group Box Protein 1 Release Is an Identified Driver of Inflammation in the Pathogenesis of Biliary Atresia
Shaojun Shi, Sunrui Chen, Monique M.A. Verstegen, Qiuwei Pan, Luc J.W. Laan – 22 June 2021
Allograft Fibrosis After Pediatric Liver Transplantation: Incidence, Risk Factors, and Evolution
Roberta Angelico, Marco Spada, Daniela Liccardo, Domiziana Pedini, Chiara Grimaldi, Andrea Pietrobattista, Maria Sole Basso, Claudia Della Corte, Antonella Mosca, Maria Cristina Saffioti, Rita Alaggio, Giuseppe Maggiore, Manila Candusso, Paola Francalanci – 22 June 2021 – Allograft fibrosis (AF) after pediatric liver transplantation (pLT) is frequent, but its dynamics are unclear. Our aim was to assess the evolution and risk factors of AF after pLT.
On the Mechanisms of Biliary Flux
Nachiket Vartak, Dirk Drasdo, Fabian Geisler, Tohru Itoh, Ronald P.J.Oude Elferink, Stan F.J. Graaf, John Chiang, Verena Keitel, Michael Trauner, Peter Jansen, Jan G. Hengstler – 22 June 2021 – Since the late 1950s, transport of bile in the liver has been described by the “osmotic concept,” according to which bile flows into the canaliculi toward the ducts, countercurrent to the blood flow in the sinusoids. However, because of the small size of canaliculi, it was so far impossible to observe, let alone to quantify this process.
Mast Cells Regulate Ductular Reaction and Intestinal Inflammation in Cholestasis Through Farnesoid X Receptor Signaling
Vik Meadows, Lindsey Kennedy, Burcin Ekser, Konstantina Kyritsi, Debjyoti Kundu, Tianhao Zhou, Lixian Chen, Linh Pham, Nan Wu, Jennifer Demieville, Laura Hargrove, Shannon Glaser, Gianfranco Alpini, Heather Francis – 22 June 2021
NAFLD and HCC: Time to Bridge the Gap
George Cholankeril, Fasiha Kanwal – 22 June 2021
Availability of a Web and Smartphone Application to Stratify the Risk of of Early Allograft Failure Requiring Liver Retransplantation
Alfonso W. Avolio, Andrea Contegiacomo, Salvatore Agnes, Giuseppe Marrone, Giovanni Moschetta, Luca Miele, Marc L. Melcher – 21 June 2021
Modeling Phenotypic Heterogeneity of Glycogen Storage Disease Type 1a Liver Disease in Mice by Somatic CRISPR/CRISPR‐associated protein 9–Mediated Gene Editing
Martijn G.S. Rutten, Terry G.J. Derks, Nicolette C.A. Huijkman, Trijnie Bos, Niels J. Kloosterhuis, Kees C.W.A. Kolk, Justina C. Wolters, Mirjam H. Koster, Laura Bongiovanni, Rachel E. Thomas, Alain Bruin, Bart Sluis, Maaike H. Oosterveer – 21 June 2021
Immunomodulatory Effects of Lenvatinib Plus Anti–Programmed Cell Death Protein 1 in Mice and Rationale for Patient Enrichment in Hepatocellular Carcinoma
Laura Torrens, Carla Montironi, Marc Puigvehí, Agavni Mesropian, Jack Leslie, Philipp K. Haber, Miho Maeda, Ugne Balaseviciute, Catherine E. Willoughby, Jordi Abril‐Fornaguera, Marta Piqué‐Gili, Miguel Torres‐Martín, Judit Peix, Daniel Geh, Erik Ramon‐Gil, Behnam Saberi, Scott L. Friedman, Derek A. Mann, Daniela Sia, Josep M. Llovet – 21 June 2021
Diagnostic Criteria of Cirrhotic Cardiomyopathy: Out With the Old, in With the New?
Hongqun Liu, Samuel S. Lee – 20 June 2021