Research methodologies to address clinical unmet needs and challenges in alcohol‐associated liver disease

Ashwani K. Singal, Paul Kwo, Allison Kwong, Suthat Liangpunsakul, Alexandre Louvet, Pranoti Mandrekar, Craig McClain, Jessica Mellinger, Gyongyi Szabo, Norah Terrault, Mark Thursz, Gerald S. Winder, W. Ray Kim, Vijay H. Shah – 7 September 2021 – Alcohol‐associated liver disease (ALD) is emerging worldwide as the leading cause of liver‐related morbidity, mortality, and indication for liver transplantation.

Ductular reaction promotes intrahepatic angiogenesis through Slit2–Roundabout 1 signaling

Mar Coll, Silvia Ariño, Celia Martínez‐Sánchez, Ester Garcia‐Pras, Javier Gallego, Anna Moles, Beatriz Aguilar‐Bravo, Delia Blaya, Julia Vallverdú, Teresa Rubio‐Tomás, Juan Jose Lozano, Elisa Pose, Isabel Graupera, Andrea Fernández‐Vidal, Albert Pol, Ramón Bataller, Jian‐Guo Geng, Pere Ginès, Mercedes Fernandez, Pau Sancho‐Bru – 6 September 2021

Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis

Pascale Gluais‐Dagorn, Marc Foretz, Gregory R. Steinberg, Battsetseg Batchuluun, Anna Zawistowska‐Deniziak, Joost M. Lambooij, Bruno Guigas, David Carling, Pierre‐Axel Monternier, David E. Moller, Sebastien Bolze, Sophie Hallakou‐Bozec – 6 September 2021 – No approved therapies are available for nonalcoholic steatohepatitis (NASH). Adenosine monophosphate–activated protein kinase (AMPK) is a central regulator of cell metabolism; its activation has been suggested as a therapeutic approach to NASH.

Subscribe to