Transcriptional Analysis of Liver Tissue Identifies Distinct Phenotypes of Indeterminate Pediatric Acute Liver Failure

Catherine A Chapin, Sarah A Taylor, Padmini Malladi, Katie Neighbors, Hector Melin‐Aldana, Portia A Kreiger, Nina Bowsher, Matthew J Schipma, Kathleen M Loomes, Edward M Behrens, Estella M Alonso – 5 May 2021 – Many patients with indeterminate pediatric acute liver failure (PALF) have evidence of T‐cell driven immune injury; however, the precise inflammatory pathways are not well defined. We have characterized the hepatic cytokine and transcriptional signatures of patients with PALF.

Extracellular Signal‐Regulated Kinase 5 Regulates the Malignant Phenotype of Cholangiocarcinoma Cells

Alessandra Gentilini, Giulia Lori, Alessandra Caligiuri, Chiara Raggi, Giovanni Di Maira, Mirella Pastore, Benedetta Piombanti, Tiziano Lottini, Annarosa Arcangeli, Stefania Madiai, Nadia Navari, Jesus M. Banales, Sabina Di Matteo, Domenico Alvaro, Lea Duwe, Jesper B. Andersen, Alessandro Tubita, Ignazia Tusa, Luca Di Tommaso, Claudia Campani, Elisabetta Rovida, Fabio Marra – 5 May 2021

Bile Salt and FGF19 Signaling in the Early Phase of Human Liver Regeneration

Kiran V.K. Koelfat, Kim M.C. Mierlo, Toine M. Lodewick, Johanne G. Bloemen, Gregory Kroft, Iakovos Amygdalos, Ulf P. Neumann, Cornelis H.C. Dejong, Peter L.M. Jansen, Steven W.M. Olde Damink, Frank G. Schaap – 4 May 2021 – The involvement of bile salt–fibroblast growth factor 19 (FGF19) signaling in human liver regeneration (LR) is not well studied. Therefore, we studied aspects of bile salt–FGF19 signaling shortly after liver resection in patients.

Characteristics and Prognosis of De Novo Hepatocellular Carcinoma After Sustained Virologic Response

Hidenori Toyoda, Atsushi Hiraoka, Haruki Uojima, Akito Nozaki, Noritomo Shimada, Koichi Takaguchi, Hiroshi Abe, Masanori Atsukawa, Kentaro Matsuura, Toru Ishikawa, Shigeru Mikami, Tsunamasa Watanabe, Ei Itobayashi, Kunihiko Tsuji, Taeang Arai, Satoshi Yasuda, Makoto Chuma, Tomonori Senoh, Akemi Tsutsui, Tomomi Okubo, Takuya Ehira, Takashi Kumada, Junko Tanaka – 4 May 2021 – Hepatocellular carcinoma (HCC) can de novo develop in patients with chronic hepatitis C even after the achievement of sustained virologic response (SVR).

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