The Co‐mutational Spectrum Determines the Therapeutic Response in Murine FGFR2 Fusion‐Driven Cholangiocarcinoma

Gajanan Kendre, Silke Marhenke, Georgina Lorz, Diana Becker, Tanja Reineke‐Plaaß, Tanja Poth, Karthikeyan Murugesan, Florian Kühnel, Norman Woller, Ralph M. Wirtz, Andreas Pich, Jens U. Marquardt, Michael Saborowski, Arndt Vogel, Anna Saborowski – 10 March 2021

An Experimental DUAL Model of Advanced Liver Damage

Raquel Benedé‐Ubieto, Olga Estévez‐Vázquez, Feifei Guo, Chaobo Chen, Youvika Singh, Helder I. Nakaya, Manuel Gómez del Moral, Arantza Lamas‐Paz, Laura Morán, Nuria López‐Alcántara, Johanna Reissing, Tony Bruns, Matías A. Avila, Eva Santamaría, Marina S. Mazariegos, Marius Maximilian Woitok, Ute Haas, Kang Zheng, Ignacio Juárez, José Manuel Martín‐Villa, Iris Asensio, Javier Vaquero, Maria Isabel Peligros, Josepmaria Argemi, Ramón Bataller, Javier Ampuero, Manuel Romero Gómez, Christian Trautwein, Christian Liedtke, Rafael Bañares, Francisco Javier Cubero, Yulia A.

Dual‐Specificity Phosphatase 9 Regulates Cellular Proliferation and Predicts Recurrence After Surgery in Hepatocellular Carcinoma

Kui Chen, Andre Gorgen, Avrilynn Ding, Lulu Du, Keruo Jiang, Yu Ding, Gonzalo Sapisochin, Anand Ghanekar – 10 March 2021 – Hepatocellular carcinoma (CC) is a common and deadly cancer with complex molecular pathogenesis. Little is known about dual‐specificity phosphatases (DUSPs) in HCC. We investigated DUSP9 expression in human HCC, associations between DUSP9 and patient outcomes, and effects of altered DUSP9 expression on HCC biology. We studied public data sets as well as 196 patients at our institution who had HCC resections.

Post–Liver Transplant Early Allograft Dysfunction Modifies the Effect of Pre–Liver Transplant Renal Dysfunction on Post–Liver Transplant Survival

Hani M. Wadei, Andrew P. Keaveny, C. Burcin Taner, Liu Yang, Martin L. Mai, David O. Hodge, Launia J. White, Shennen A. Mao, Tambi Jarmi, Kristopher P. Croome – 8 March 2021 – Pre–liver transplantation (LT) renal dysfunction is associated with poor post‐LT survival. We studied whether early allograft dysfunction (EAD) modifies this association. Data on 2,856 primary LT recipients who received a transplant between 1998 and 2018 were retrospectively reviewed. Patients who died within the first post‐LT week or received multiorgan transplants and previous LT recipients were excluded.

Association of Donor and Recipient Cytomegalovirus Serostatus on Graft and Patient Survival in Liver Transplant Recipients

Philip Vutien, James Perkins, Scott W. Biggins, Jorge Reyes, Hannah Imlay, Ajit P. Limaye – 8 March 2021 – Among solid organ transplant recipients, donor cytomegalovirus (CMV) seropositive (D+) and recipient seronegative (R−) status are associated with an increased risk of graft loss and mortality after kidney or lung transplantation. Whether a similar relationship exists among liver transplant recipients (LTR) is unknown. We assessed graft loss and mortality among adult LTRs from January 1, 2010, to March 14, 2020, in the Organ Procurement and Transplantation Network database.

Cancer‐Associated Fibroblast‐Mediated Cellular Crosstalk Supports Hepatocellular Carcinoma Progression

Mengjia Song, Junyi He, Qiu‐Zhong Pan, Jieying Yang, Jingjing Zhao, Yao‐Jun Zhang, Yue Huang, Yan Tang, Qijing Wang, Jia He, Jiamei Gu, Yongqiang Li, Shiping Chen, Jianxiong Zeng, Zi‐Qi Zhou, Chaopin Yang, Yulong Han, Hao Chen, Tong Xiang, De‐Sheng Weng, Jian‐Chuan Xia – 7 March 2021

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