A Dynamic Aspartate‐to‐Alanine Aminotransferase Ratio Provides Valid Predictions of Incident Severe Liver Disease

Fredrik Åberg, Christopher J. Danford, Maja Thiele, Mats Talbäck, Ditlev Nytoft Rasmussen, Z. Gordon Jiang, Niklas Hammar, Patrik Nasr, Mattias Ekstedt, Anna But, Pauli Puukka, Aleksander Krag, Jouko Sundvall, Iris Erlund, Veikko Salomaa, Per Stål, Stergios Kechagias, Rolf Hultcrantz, Michelle Lai, Nezam Afdhal, Antti Jula, Satu Männistö, Annamari Lundqvist, Markus Perola, Martti Färkkilä, Hannes Hagström – 7 March 2021 – The aspartate‐to‐alanine aminotransferase ratio (AAR) is associated with liver fibrosis, but its predictive performance is suboptimal.

Metabolomic Analysis Uncovers Energy Supply Disturbance as an Underlying Mechanism of the Development of Alcohol‐Associated Liver Cirrhosis

Ying Huang, Ming Niu, Jing Jing, Zi‐teng Zhang, Xu Zhao, Shuai‐shuai Chen, Shan‐shan Li, Zhuo Shi, Ang Huang, Zheng‐Sheng Zou, Yue‐cheng Yu, Xiao‐he Xiao, Suthat Liangpunsakul, Jia‐bo Wang – 7 March 2021 – Alcohol‐associated liver disease (ALD) is caused by alcohol metabolism’s effects on the liver. The underlying mechanisms from a metabolic view in the development of alcohol‐associated liver cirrhosis (ALC) are still elusive.

COVID‐19 Aftershocks on Alcohol‐Associated Liver Disease: An Early Cross‐Sectional Report From the U.S. Epicenter

Stephanie M. Rutledge, Thomas D. Schiano, Sander Florman, Gene Y. Im – 4 March 2021 – Experts have forewarned about the coronavirus disease 2019 (COVID‐19) pandemic environment fomenting the rising incidence of alcohol use disorder (AUD) and alcohol‐associated liver disease (ALD). We performed a cross‐sectional study of ALD at our liver transplantation (LT) center, located in the initial U.S. epicenter, New York City.

Impact of Genotype, Serum Bile Acids, and Surgical Biliary Diversion on Native Liver Survival in FIC1 Deficiency

Daan B.E. Wessel, Richard J. Thompson, Emmanuel Gonzales, Irena Jankowska, Benjamin L. Shneider, Etienne Sokal, Tassos Grammatikopoulos, Agustina Kadaristiana, Emmanuel Jacquemin, Anne Spraul, Patryk Lipiński, Piotr Czubkowski, Nathalie Rock, Mohammad Shagrani, Dieter Broering, Talal Algoufi, Nejat Mazhar, Emanuele Nicastro, Deirdre Kelly, Gabriella Nebbia, Henrik Arnell, Björn Fischler, Jan B.F.

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