Persistent Control of Hepatitis B Virus and Hepatitis Delta Virus Infection Following REP 2139‐Ca and Pegylated Interferon Therapy in Chronic Hepatitis B Virus/Hepatitis Delta Virus Coinfection

Michel Bazinet, Victor Pântea, Valentin Cebotarescu, Lilia Cojuhari, Pavlina Jimbei, Mark Anderson, Jeff Gersch, Vera Holzmayer, Carina Elsner, Adalbert Krawczyk, Mary C. Kuhns, Gavin Cloherty, Ulf Dittmer, Andrew Vaillant – 13 November 2020 – The nucleic acid polymer REP 2139 inhibits assembly/secretion of hepatitis B virus (HBV) subviral particles. Previously, REP 2139‐Ca and pegylated interferon (pegIFN) in HBV/hepatitis delta virus (HDV) coinfection achieved high rates of HDV RNA and hepatitis B surface antigen (HBsAg) loss/seroconversion in the REP 301 study (NCT02233075).

Hepatic Stellate Cell Regulation of Liver Regeneration and Repair

Laura J. Kitto, Neil C. Henderson – 13 November 2020 – The hepatic mesenchyme has been studied extensively in the context of liver fibrosis; however, much less is known regarding the role of mesenchymal cells during liver regeneration. As our knowledge of the cellular and molecular mechanisms driving hepatic regeneration deepens, the key role of the mesenchymal compartment during the regenerative response has been increasingly appreciated.

Aspirin Use Is Associated with a Reduced Incidence of Hepatocellular Carcinoma: A Systematic Review and Meta‐analysis

Zoe N. Memel, Ashwini Arvind, Oluwatoba Moninuola, Lisa Philpotts, Raymond T. Chung, Kathleen E. Corey, Tracey G. Simon – 13 November 2020 – Hepatocellular carcinoma (HCC) is the third‐leading cause of cancer‐related death worldwide, with a growing incidence and poor prognosis. While some recent studies suggest an inverse association between aspirin use and reduced HCC incidence, other data are conflicting. To date, the precise magnitude of risk reduction—and whether there are dose‐dependent and duration‐dependent associations—remains unclear.

Point Shear‐Wave Elastography Using Acoustic Radiation Force Impulse Imaging for the Prediction of Liver‐Related Events in Patients With Chronic Viral Hepatitis

Lisa Hernandez Sampere, Johannes Vermehren, Victoria T. Mücke, Christiana Graf, Kai‐Henrik Peiffer, Georg Dultz, Stefan Zeuzem, Oliver Waidmann, Natalie Filmann, Joerg Bojunga, Christoph Sarrazin, Mireen Friedrich‐Rust, Marcus M. Mücke – 12 November 2020 – Chronic viral hepatitis is associated with substantial morbidity and mortality worldwide.

Hepatic Predictors of Mortality in Severe Acute Respiratory Syndrome Coronavirus 2: Role of Initial Aspartate Aminotransferase/Alanine Aminotransferase and Preexisting Cirrhosis

Shalom Z. Frager, James Szymanski, Jonathan M. Schwartz, Hatef S. Massoumi, Milan Kinkhabwala, Allan W. Wolkoff – 11 November 2020 – The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS‐CoV2) is the causative agent of coronavirus disease 2019 (COVID‐19). The presenting symptoms of this virus are variable, and there is an increasing body of literature on risk factors for mortality.

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