Neutral Ceramidase Mediates Nonalcoholic Steatohepatitis by Regulating Monounsaturated Fatty Acids and Gut IgA+ B Cells
Xuemei Gu, Rui Sun, Liang Chen, Shenghui Chu, Mark A. Doll, Xiaohong Li, Wenke Feng, Leah Siskind, Craig J. McClain, Zhongbin Deng – 13 November 2020
Ursodeoxycholic Acid Decreases Incidence of Primary Biliary Cholangitis and Biliary Complications After Liver Transplantation: A Meta‐Analysis
Mark R. Pedersen, Garrett Greenan, Sumant Arora, Arvind R. Murali, Marlyn J. Mayo – 13 November 2020 – After liver transplantation (LT), the role of ursodeoxycholic acid (UDCA) is not well characterized. We examine the effect of UDCA after LT in the prophylaxis of biliary complications (BCs) in all‐comers for LT and the prevention of recurrent primary biliary cholangitis (rPBC) in patients transplanted for PBC.
Impact of Payer Status on Delisting Among Liver Transplant Candidates in the United States
Krystal L. Karunungan, Yas Sanaiha, Roland A. Hernandez, Holly Wilhalme, Sarah Rudasill, Joseph Hadaya, Joseph DiNorcia, Peyman Benharash – 13 November 2020 – Although socioeconomic disparities persist both pre‐ and post‐transplantation, the impact of payer status has not been studied at the national level. We examined the association between public insurance coverage and waitlist outcomes among candidates listed for liver transplantation (LT) in the United States.
Hepatic Stellate Cell Regulation of Liver Regeneration and Repair
Laura J. Kitto, Neil C. Henderson – 13 November 2020 – The hepatic mesenchyme has been studied extensively in the context of liver fibrosis; however, much less is known regarding the role of mesenchymal cells during liver regeneration. As our knowledge of the cellular and molecular mechanisms driving hepatic regeneration deepens, the key role of the mesenchymal compartment during the regenerative response has been increasingly appreciated.
Persistent Control of Hepatitis B Virus and Hepatitis Delta Virus Infection Following REP 2139‐Ca and Pegylated Interferon Therapy in Chronic Hepatitis B Virus/Hepatitis Delta Virus Coinfection
Michel Bazinet, Victor Pântea, Valentin Cebotarescu, Lilia Cojuhari, Pavlina Jimbei, Mark Anderson, Jeff Gersch, Vera Holzmayer, Carina Elsner, Adalbert Krawczyk, Mary C. Kuhns, Gavin Cloherty, Ulf Dittmer, Andrew Vaillant – 13 November 2020 – The nucleic acid polymer REP 2139 inhibits assembly/secretion of hepatitis B virus (HBV) subviral particles. Previously, REP 2139‐Ca and pegylated interferon (pegIFN) in HBV/hepatitis delta virus (HDV) coinfection achieved high rates of HDV RNA and hepatitis B surface antigen (HBsAg) loss/seroconversion in the REP 301 study (NCT02233075).
Point Shear‐Wave Elastography Using Acoustic Radiation Force Impulse Imaging for the Prediction of Liver‐Related Events in Patients With Chronic Viral Hepatitis
Lisa Hernandez Sampere, Johannes Vermehren, Victoria T. Mücke, Christiana Graf, Kai‐Henrik Peiffer, Georg Dultz, Stefan Zeuzem, Oliver Waidmann, Natalie Filmann, Joerg Bojunga, Christoph Sarrazin, Mireen Friedrich‐Rust, Marcus M. Mücke – 12 November 2020 – Chronic viral hepatitis is associated with substantial morbidity and mortality worldwide.
Doublecortin‐Like Kinase Protein 1 in Cholangiocarcinoma: Is This the Biomarker and Target We Have Been Looking For?
Vik Meadows, Heather Francis – 11 November 2020
MRI‐Proton Density Fat Fraction Treatment Response Criteria in Nonalcoholic Steatohepatitis
Rohit Loomba – 11 November 2020
Hepatic Predictors of Mortality in Severe Acute Respiratory Syndrome Coronavirus 2: Role of Initial Aspartate Aminotransferase/Alanine Aminotransferase and Preexisting Cirrhosis
Shalom Z. Frager, James Szymanski, Jonathan M. Schwartz, Hatef S. Massoumi, Milan Kinkhabwala, Allan W. Wolkoff – 11 November 2020 – The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS‐CoV2) is the causative agent of coronavirus disease 2019 (COVID‐19). The presenting symptoms of this virus are variable, and there is an increasing body of literature on risk factors for mortality.