| AASLD

<div>Background: Patients with decompensated cirrhosis are frequently hospitalized and often undergo multiple invasive procedures. We aimed to define the incidence of procedural-related bleeding in patients with acute on chronic liver failure (ACLF) and to compare it with that of patients without ACLF.

LIPID INDUCED ENDOTHELIAL INTERCELLULAR ADHESION MOLECULE 1 (ICAM1) PROMOTES METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS

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<div>Background: During metabolic dysfunction-associated steatohepatitis (MASH), liver sinusoidal endothelial cells (LSECs) acquire a pro-inflammatory phenotype characterized by increased adhesion molecules expression and myeloid cells-associated liver inflammation culminating in disease progression. However, the exact molecular mediators of this phenomenon are unclear.

IMMUNE SYSTEM IN THE LIVER OF POST-TRANSPLANT ALLOIMMUNE HEPATITIS AND AUTOIMMUNE HEPATITIS PATIENTS TIPPED IN FAVOR OF NON-SUPPRESSIVE MECHANISMS.

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<div>Background: Peripheral blood (PB) regulatory T cells (Tregs) in post-transplant alloimmune hepatitis (DAIH) & autoimmune hepatitis (AIH) have poor regulatory function, however little is known about intrahepatic (IH) Tregs in both diseases.

ANONYMOUS LIVING LIVER DONATION IMPROVES ACCESS FOR MEDICALLY UNDERSERVED CHILDREN IN NEED OF LIVER TRANSPLANTATION: THE CANADIAN EXPERIENCE

Read more about ANONYMOUS LIVING LIVER DONATION IMPROVES ACCESS FOR MEDICALLY UNDERSERVED CHILDREN IN NEED OF LIVER TRANSPLANTATION: THE CANADIAN EXPERIENCE

<div>Background: Since our first pediatric anonymous non-directed live donor liver transplant (Anon-LDLT) performed in April 2005, 62 children have undergone live donor liver transplant (LDLT) with an anonymous non-directed graft. Anon-LDLT organs being allocated as per our deceased donor liver transplant wait list.

IMPROVED MEAN ARTERIAL PRESSURE FROM BASELINE TO THE END OF TREATMENT WITH TERLIPRESSIN IS ASSOCIATED WITH HEPATORENAL SYNDROME REVERSAL: A POOLED ANALYSIS OF 3 PHASE III STUDIES

Read more about IMPROVED MEAN ARTERIAL PRESSURE FROM BASELINE TO THE END OF TREATMENT WITH TERLIPRESSIN IS ASSOCIATED WITH HEPATORENAL SYNDROME REVERSAL: A POOLED ANALYSIS OF 3 PHASE III STUDIES

<div>Background: Hepatorenal syndrome type 1 (HRS-1) is a rapidly progressive form of renal failure associated with high mortality in patients (pts) with decompensated cirrhosis and ascites. The FDA-approved vasopressin analogue, terlipressin (terli), improves renal function in pts with HRS-1 by reducing portal hypertension and increasing effective arterial volume and mean arterial pressure (MAP)—a marker of the hemodynamic response to treatment.

STAT3 SIGNALING MEDIATES FXR AGONIST PROTECTION IN ACUTE CHOLANGIOPATHY MOUSE MODEL

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<div>Background: Primary sclerosing cholangitis (PSC), a chronic cholangiopathy, results in cholestasis, inflammation, and stricturing of intrahepatic and extrahepatic bile ducts. Recently, we have shown that the transcription factor STAT3 mediated, in part, the protective role of the FXR agonist, GW4064, in parenteral nutrition (PN)-associated cholestasis (Ghosh et al., Hep comm 2023).

CENTER-SPECIFIC DATA FROM THE INTERNATIONAL MULTICENTER PEDIATRIC PORTAL HYPERTENSION REGISTRY (IMPPHR) – INITIAL ANALYSES OF 23 INTERNATIONAL SITES

Read more about CENTER-SPECIFIC DATA FROM THE INTERNATIONAL MULTICENTER PEDIATRIC PORTAL HYPERTENSION REGISTRY (IMPPHR) – INITIAL ANALYSES OF 23 INTERNATIONAL SITES

<div>Background: There are very limited high-quality data from which to derive therapeutic approaches to portal hypertension (PHT) in children. Management of varices, in particular, is quite controversial in pediatrics. IMPPHR was developed to derive large-scale international data, thereby enhancing our knowledge of PHT.

ELUCIDATING THE MECHANISMS OF KIF12-MEDIATED HIGH GGT CHOLESTASIS

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<div>Background: We and others have shown that rare bi-allelic loss-of-function mutations in Kinesin family member 12 (KIF12) cause pediatric high-GGT cholestasis as well as fibrosis, ductular reaction, and bile duct loss. KIF12 has putatively been defined as a microtubule-associated motor protein, but little is known about its function and even less about its role in the pathogenesis of cholestasis.

CARVEDILOL PLUS NUCS TO PREVENT THE PROGRESSION OF ESOPHAGEAL VARICES IN VIROLOGICAL SUPPRESSED HBV-CIRRHOSIS PATIENTS: A RANDOMISED, OPEN-LABEL TRIAL.

Read more about CARVEDILOL PLUS NUCS TO PREVENT THE PROGRESSION OF ESOPHAGEAL VARICES IN VIROLOGICAL SUPPRESSED HBV-CIRRHOSIS PATIENTS: A RANDOMISED, OPEN-LABEL TRIAL.

<div>Background: Portal hypertension progression can be relieved after controlling the etiology of liver cirrhosis. Whether beta-blockers could additionally enhance the effects during treatment, particularly for mild esophageal varices (EVs), was unclear. This study aims to assess the efficacy of add-on carvedilol to delay EVs progression during anti-HBV treatment in HBV-related cirrhosis.

CIRCULATING CLASSICAL MONOCYTE-DERIVED IL-1β PRODUCTION IS ASSOCIATED WITH THE REDUCTION OF SERUM HBsAg LEVELS IN CHRONIC HEPATITIS B

Read more about CIRCULATING CLASSICAL MONOCYTE-DERIVED IL-1β PRODUCTION IS ASSOCIATED WITH THE REDUCTION OF SERUM HBsAg LEVELS IN CHRONIC HEPATITIS B

<div>Background: Although nucleotide analogs (NA) prevent viral replication in chronic hepatitis B (CHB) patients, it rarely achieve HBsAg seroclearance. While the reduction of HBsAg levels is associated with HBsAg seroclearance, the factors regulating HBsAg levels are not well understood. To aim for “Functional Cure”, we explored the host immunodynamics involved in the reduction of HBsAg levels.

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