| AASLD

<div>Background: Patients with decompensated cirrhosis (DC) often experience high psychological symptom burden. Family caregivers of patients with DC are at risk for psychological distress.

MACHINE LEARNING PREDICTS DIETARY PATTERNS ASSOCIATED WITH FATTY LIVER DISEASE PROTECTION

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<div>Background: Non-alcoholic fatty liver disease (NAFLD) affects a substantial proportion of the general population, but little is known about the impact of specific nutrients on its prevention. Utilizing unbiased machine learning, we aimed to investigate the association between dietary nutrients and the development of NAFLD in the large UK Biobank dataset.

PEGYLATED INTERFERON REDUCES RELAPSES FOLLOWING BEPIROVIRSEN TREATMENT IN PARTICIPANTS WITH CHRONIC HEPATITIS B VIRUS INFECTION ON NUCLEOS(T)IDE ANALOGUES: END OF STUDY RESULTS FROM THE PHASE 2b B-TOGETHER STUDY

Read more about PEGYLATED INTERFERON REDUCES RELAPSES FOLLOWING BEPIROVIRSEN TREATMENT IN PARTICIPANTS WITH CHRONIC HEPATITIS B VIRUS INFECTION ON NUCLEOS(T)IDE ANALOGUES: END OF STUDY RESULTS FROM THE PHASE 2b B-TOGETHER STUDY

<div>Background: In the Phase 2b B-Clear study (209668), bepirovirsen (BPV; an antisense oligonucleotide) 300 mg for 24 weeks (wks) achieved sustained HBsAg and HBV DNA loss (<lower limit of quantification [LLOQ] for 24 wks off BPV therapy) in 9% of participants (pts) who remained on nucleos[t]ide analogs (NA); end of BPV response rates were higher (26%), but some pts relapsed during follow-up. Response was higher in pts with lower baseline HBsAg (≤3000 vs ≤1000 IU/mL: 12% vs 16%).

COMPARISON OF RECURRENCE PREDICTION MODELS AND IMBRAVE 050 CRITERIA TO SELECT PATIENTS FOR ADJUVANT IMMUNOTHERAPY AFTER CURATIVE RESECTION OF HEPATOCELLULAR CARCINOMA

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<div>Background:

SATURATED FAT FAVORABLY ALTERS THE GUT MICROBIOTA AND IMPROVES SURVIVAL IN PATIENTS WITH SEVERE ALCOHOLIC HEPATITIS: A RANDOMIZED CONTROLLED TRIAL

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<div>Background: Severe alcoholic hepatitis (SAH) is associated with malnutrition, dysbiosis and inflammatory cytokines augmenting liver injury resulting in high mortality. Experimental studies have reported that in comparison to unsaturated fat (UF), saturated fat (SF) improves dysbiosis, inflammation, liver enzymes and protects against alcoholic liver injury, but effect on clinical outcome and gut microbiota (GM) in SAH patients is lacking.

EZURPIMTROSTAT AUTOPHAGY BLOCKER, A PALMITOYL-PROTEIN THIOESTERASE 1 (PPT1) INHIBITOR, AND ATEZOLIZUMAB/BEVACIZUMAB TRIPLE COMBINATION REGIMEN ENHANCES ANTITUMOR EFFICACY IN HEPATOCELLULAR CARCINOMA

Read more about EZURPIMTROSTAT AUTOPHAGY BLOCKER, A PALMITOYL-PROTEIN THIOESTERASE 1 (PPT1) INHIBITOR, AND ATEZOLIZUMAB/BEVACIZUMAB TRIPLE COMBINATION REGIMEN ENHANCES ANTITUMOR EFFICACY IN HEPATOCELLULAR CARCINOMA

<div>Background: Immune checkpoint therapies combination with anti-VEGF is the standard-of-care in first-line of hepatocellular carcinoma (HCC). However, only 30 % of patients present a response to first line therapy. Autophagy inhibitors were recently spotted out as a potential robust strategy to promote antigen presentation and therefore reinforce immune checkpoint inhibitors (ICIs) potency conducting to strong anti-tumoral response.

PHENOTYPIC CLUSTERING IDENTIFIES HIGH-RISK PROFILES FOR SARCOPENIA & 1-YEAR POST-TRANSPLANT MORTALITY IN PATIENTS WITH END-STAGE LIVER DISEASE

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<div>Background: Sarcopenia in end-stage liver disease (ESLD) has been identified as a risk factor for increased mortality. Radiological parameters; psoas muscle area index (PMAI) & transverse psoas muscle thickness index (TPMTI) assess muscle quantity. While psoas muscle density index (PMDI) assesses muscle quality. Both identify muscle wasting, atrophy & myosteatosis.

SINGLE-CELL ANALYSES IDENTIFY ENRICHMENT OF Th1 CELLS IN MURINE NONALCOHOLIC STEATOHEPATITIS

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<div>Background: Nonalcoholic steatohepatitis (NASH) is a progressive disease characterized by liver inflammation. Emerging evidence implicates T cells in the disease pathogenesis. Our unpublished data show that CD4 T cells contribute to NASH development; however, hepatic CD4 T cell phenotypes and functions in NASH have not yet been systematically examined.

STAKEHOLDER ENGAGEMENT TO IDENTIFY KEY DETERMINANTS OF VIRAL HEPATITIS AND LIVER CANCER SCREENING AND CARE IN ASIAN AMERICAN COMMUNITIES

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<div>Background: Viral hepatitis screening and link to care is a key cancer control strategy to prevent development of liver cancer, especially in underserved populations. We lack data on determinants for viral hepatitis and liver cancer screening and care particularly in geographically spread Asian American (AA) populations.

SOCIAL DETERMINANTS OF HEALTH ARE ASSOCIATED WITH ADHERENCE TO MONITORING AMONG IMMIGRANTS WITH CHRONIC HEPATITIS B: A MULTICENTER STUDY

Read more about SOCIAL DETERMINANTS OF HEALTH ARE ASSOCIATED WITH ADHERENCE TO MONITORING AMONG IMMIGRANTS WITH CHRONIC HEPATITIS B: A MULTICENTER STUDY

<div>Background: Immigrants are the largest subgroup living with chronic hepatitis B (HBV) infection in the United States (US). Close monitoring is recommended for all patients with chronic HBV regardless of disease activity. It is not well understood how immigration factors and social determinants of health (SDOH) impact downstream adherence to HBV monitoring among immigrants.

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