<div><p><strong>Background</strong>: Systemic inflammation is known as a major role in pathogenesis of acute-on-chronic liver failure (ACLF) from cross-sectional studies, but its detailed impacts on the dynamic trajectory of this disease from the absence of organ dysfunction (OD) to onset of OD, organ failure (OF) and eventual ACLF remains poorly understood due to challenges in collecting data and samples from individuals. Multinomial and ordinal regression analyses are useful tools to circumvent the limitation intrinsic to cross-sectional studies in cirrhosis.

<div><p><b>Background: </b>New therapeutic alternatives to corticosteroids in severe alcohol-associated hepatitis (SAH) is unmet need. Fecal microbiota transplantation (FMT) has been proposed as it targets well-established pathophysiological pathway but, data is scarce and many unanswered questions remain. One of the principal tools for personalized management of SAH is selection of patients whose potential to benefit from FMT is increased based on their pre-FMT gut-microbiome analysis.</p>

<div><p><b>Background:<span data-contrast="auto" xml:lang="EN-CA" lang="EN-CA" class="TextRun SCXW165043786 BCX0"> </b><span class="NormalTextRun SCXW165043786 BCX0">Multimodal treatment for pediatric liver tumors</span><span class="NormalTextRun SCXW165043786 BCX0">, including indications for transplantation,</span><span class="NormalTextRun SCXW165043786 BCX0"> has evolved over the last several</span><span class="NormalTextRun SCXW165043786 BCX0&q

<div><p><b>Background: </b>Immune checkpoints (CTLA4 &amp; PD1) are inhibitory pathways that block aberrant immune activity and maintain self-tolerance. Tumors co-opt these checkpoints to avoid immune destruction. Immune Checkpoint Inhibitors (ICIs) activate immune cells and restore their tumoricidal potential, making them highly efficacious cancer therapies.

<div><p><b>Background:</p> </b><div><p><span lang="EN-US">Despite recent developments, it is still very difficult to differentiate hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (iCCA). Clinically available methods such as CT, MRI, and contrast-enhanced ultrasound require the highest level of investigator experience to reliably differentiate between HCC and iCCA.

<div><p><b>Background:</p> </b><p style="font-weight: 400;">Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) has extremely high prevalence in the US and globally with increasing incidence of morbidity and mortality in the population.

<div><p><b>Background: </b>Cross-sectional studies have identified individuals from sub-Saharan Africa with (SSA) chronic hepatitis B (CHB) as a potential risk group for hepatocellular carcinoma (HCC) and advocate enrolment in an HCC surveillance program even in the absence of cirrhosis. However, the incidence of HCC and performance of HCC risk scores in this population are unknown.</p>

<div><p><b>Background: </b>The rising prevalence of alcohol-associated liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) has led to increases in the need for liver transplantation (LT). The purpose of our study was to investigate disparities in access to LT, and whether those disparities were consistent across etiology of liver disease.</p>

<div><p><b>Background: </b>Food insecurity can increase the risk for NAFLD. We assessed the association between food insecurity and NAFLD among adolescents in the United States.</p>

<div><p><strong><b>Background:<span> </b></span></strong>Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death, with high morbidity and mortality among vulnerable populations. We hypothesized the social determinants of health (SDOH), downstream social risks, and health behaviors impact access to curative therapies.</p>