Hepatobiliary Organoids and Their Applications for Studies of Liver Health and Disease: Are We There Yet?

Junya Shiota, Linda C. Samuelson, Nataliya Razumilava – 25 February 2021 – Organoid culture systems have emerged as a frontier technology in liver and biliary research. These three‐dimensional (3D) cell cultures derived from pluripotent and adult hepatobiliary cells model organ structure and function. Building on gastrointestinal organoid establishment, hepatobiliary organoid cultures were generated from mouse leucine‐rich repeat–containing G‐protein–coupled receptor 5–positive liver progenitor cells.

Multiparametric Magnetic Resonance Imaging, Autoimmune Hepatitis, and Prediction of Disease Activity

Katherine Arndtz, Elizabeth Shumbayawonda, James Hodson, Peter J. Eddowes, Andrea Dennis, Helena Thomaides‐Brears, Sofia Mouchti, Matt D. Kelly, Rajarshi Banerjee, Stefan Neubauer, Gideon M. Hirschfield – 22 February 2021 – Noninvasive monitoring of disease activity in autoimmune hepatitis (AIH) has potential advantages for patients for whom liver biopsy is invasive and with risk. We sought to understand the association of multiparametric magnetic resonance imaging (mpMRI) with clinical course of patients with AIH.

Higher Mortality in Pediatric Liver Transplant Candidates With Sarcopenia

Julia M. Boster, Lorna P. Browne, Zhaoxing Pan, Wenru Zhou, Peter F. Ehrlich, Shikha S. Sundaram – 22 February 2021 – Little is known about the impact of sarcopenia (reduced muscle mass and function) in pediatric chronic liver disease. We compared psoas muscle surface area (PMSA), measured at the 4th lumbar vertebrae, in children listed for liver transplantation (LT) to that of healthy controls and studied the impact of sarcopenia on transplant‐associated outcomes.

Fructose Protects Against Acetaminophen‐Induced Hepatotoxicity Mainly by Activating the Carbohydrate‐Response Element‐Binding Protein α–Fibroblast Growth Factor 21 Axis in Mice

Deqiang Zhang, Sujuan Wang, Erin Ospina, Omar Shabandri, Daniel Lank, Jephte Y. Akakpo, Zifeng Zhao, Meichan Yang, Jun Wu, Hartmut Jaeschke, Pradip Saha, Xin Tong, Lei Yin – 22 February 2021 – Acetaminophen (N‐acetyl‐para‐aminophenol [APAP]) overdose is the most common cause of drug‐induced liver injury in the Western world and has limited therapeutic options. As an important dietary component intake, fructose is mainly metabolized in liver, but its impact on APAP‐induced liver injury is not well established.

Living Donor Liver Transplantation in the United States: Evolution of Frequency, Outcomes, Center Volumes, and Factors Associated With Outcomes

Thomas G. Cotter, Mohamad Minhem, Jennifer Wang, Thoetchai Peeraphatdit, Fares Ayoub, Anjana Pillai, Roberto Hernandez‐Alejandro, Diego Sabato, Michael Charlton – 21 February 2021 – Recent modifications in organ allocation policies and increases in chronic liver diseases may have resulted in important changes in living donor liver transplantation (LDLT) in the United States. We examined the trends, outcomes, and factors associated with outcomes in adult LDLT.

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