Mortality of NAFLD According to the Body Composition and Presence of Metabolic Abnormalities

Pegah Golabi, James M. Paik, Tamoore Arshad, Youssef Younossi, Alita Mishra, Zobair M. Younossi – 19 May 2020 – Although nonalcoholic fatty liver disease (NAFLD) is associated with obesity, it can also occur in lean and metabolically normal individuals. Our aim was to determine the effect of different combinations of abdominal adiposity and overall adiposity on the mortality of NAFLD. The Third National Health and Nutrition Examination Survey with mortality data from the National Death Index were used. NAFLD was defined as steatosis without other liver diseases.

Disulfide High‐Mobility Group Box 1 Drives Ischemia‐Reperfusion Injury in Human Liver Transplantation

Rebecca A. Sosa, Allyson Q. Terry, Fady M. Kaldas, Yi‐Ping Jin, Maura Rossetti, Takahiro Ito, Fang Li, Richard S. Ahn, Bita V. Naini, Victoria M. Groysberg, Ying Zheng, Antony Aziz, Jessica Nevarez‐Mejia, Ali Zarrinpar, Ronald W. Busuttil, David W. Gjertson, Jerzy W. Kupiec‐Weglinski, Elaine F. Reed – 19 May 2020

Genome‐Wide Association Study of Lean Nonalcoholic Fatty Liver Disease Suggests Human Leukocyte Antigen as a Novel Candidate Locus

Ken Yoshida, Kazuha Yokota, Yukinobu Kutsuwada, Kazuhiro Nakayama, Kazuhisa Watanabe, Ayumi Matsumoto, Hiroshi Miyashita, Seik‐soon Khor, Katsushi Tokunaga, Yosuke Kawai, Masao Nagasaki, Sadahiko Iwamoto – 19 May 2020 – Nonalcoholic fatty liver disease (NAFLD) is supposed to manifest its metabolic phenotype in the liver, but it is common to have lean individuals diagnosed with NAFLD, known as lean NAFLD. We conducted a two‐stage analysis to identify NAFLD‐associated loci in Japanese patients.

Hepatology Highlights

Joseph F. Pisa, Robert S. Brown, Petra Hirsova, Robert E. Schwartz, Tejasav S. Sehrawat, Nicholas W. Russo, Enis Kostallari, Zaid H. Tafesh, Brett Fortune, Hirsh D. Trivedi, Daryl T.Y. Lau, Angel Morales‐Santiago, Joel Wedd, Samuel C. Buchl, Jessica L. Maiers – 18 May 2020

Understanding the Final Disposition of Livers Declined After the Start of Procurement: A Nationwide Organ Procurement Organization Effort

Nikole A. Neidlinger, Christopher Brown, Patrick Wood, Jeff Traseger, Dan Lebovitz, Roxane Cauwels, Shareef Syed, Justin R. Parekh, Garrett R. Roll – 17 May 2020 – Declining a liver offer during organ procurement likely increases the risk of discard, but the specifics around late reallocation remain obscure. This voluntarily submitted, prospectively collected data describe late declines and the ultimate disposition of 893 livers. Once a liver suffered an intraoperative decline, only 49% of recovered livers were transplanted.

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