Opioid Minimization After Liver Transplantation: Results of a Novel Pilot Study
Tiffany C. Lee, Lacey Bittel, Tiffany E. Kaiser, R. Cutler Quillin, Courtney Jones, Shimul A. Shah – 23 June 2020
Nonalcoholic Fatty Liver Disease Increases the Risk of Anxiety and Depression
Christian Labenz, Yvonne Huber, Maurice Michel, Michael Nagel, Peter R. Galle, Karel Kostev, Jörn M. Schattenberg – 22 June 2020 – Nonalcoholic fatty liver disease (NAFLD), depression, and anxiety disorders are frequent diseases, and data on mutual influence are inconsistent. The aim of this study was to explore the incidence of depression and anxiety in a large primary care cohort in Germany and to study the impact of NAFLD over a 10‐year time frame.
An Endoplasmic Reticulum Stress–MicroRNA‐26a Feedback Circuit in NAFLD
Haixia Xu, Yan Tian, Dongmei Tang, Sailan Zou, Geng Liu, Jiulin Song, Guixiang Zhang, Xiao Du, Wei Huang, Bin He, Weiqiang Lin, Liang Jin, Wendong Huang, Jiayin Yang, Xianghui Fu – 22 June 2020
The Microbiome and Hepatocellular Carcinoma
Puru Rattan, Carlos D. Minacapelli, Vinod Rustgi – 21 June 2020 – The human microbiome is a vast and complex system encompassing all of the microbes and their genes that occupy the environmentally exposed surfaces of the human body. The gut microbiota and its associated microbiome play an integral role in mammalian metabolism and immune tolerance as well as in immunocompetence. Disruptions in the human gut microbiome are associated with a cycle of hepatocyte injury and regeneration characteristic of chronic liver disease.
Low Health Literacy Is Associated With Frailty and Reduced Likelihood of Liver Transplant Listing: A Prospective Cohort Study
Therese Bittermann, Kristen Dwinnells, Sakshum Chadha, Michael S. Wolf, Kim M. Olthoff, Marina Serper – 21 June 2020 – The effect of low health literacy (HL) on outcomes in end‐stage liver disease (ESLD) is largely unknown. The association of low HL on clinical outcomes was investigated in a prospective cohort of outpatients with ESLD undergoing liver transplantation (LT) evaluation. From 2014 to 2017, 276 patients underwent LT evaluation with assessments of liver disease severity, medical and psychosocial comorbidities, physical frailty, and malnutrition.
Letter to the Editor: Congenital Extrahepatic Portosystemic Shunts (Abernethy Malformation): A New Variant
Vijay Waman Dhakre, Preet Shah, Sanjay S. Nagral, Aabha Nagral – 20 June 2020
Primary Treatment with Molecular‐Targeted Agents for Hepatocellular Carcinoma: A Propensity Score‐matching Analysis
Masahito Nakano, Ryoko Kuromatsu, Takashi Niizeki, Shusuke Okamura, Hideki Iwamoto, Shigeo Shimose, Tomotake Shirono, Yu Noda, Naoki Kamachi, Hironori Koga, Takuji Torimura, The Kurume Liver Cancer Study Group of Japan – 20 June 2020 – Sorafenib and lenvatinib, as molecular‐targeted agents, constitute effective primary treatment options for advanced hepatocellular carcinoma (HCC). However, the choice of optimal primary treatment agent remains controversial.
Finding the Right Balance for the Use of Donation After Circulatory Death Livers for Patients With Hepatocellular Carcinoma
David D. Lee, Scott J. Cotler – 20 June 2020
Clinical Significance of Spontaneous Portosystemic Shunts in Living Donor Liver Transplantation
Toru Ikegami, Kenei Furukawa, Yoshihiro Shirai, Jyungo Yasuda, Takeshi Gocho – 19 June 2020
Intravital Dynamic and Correlative Imaging of Mouse Livers Reveals Diffusion‐Dominated Canalicular and Flow‐Augmented Ductular Bile Flux
Nachiket Vartak, Georgia Guenther, Florian Joly, Amruta Damle‐Vartak, Gudrun Wibbelt, Jörns Fickel, Simone Jörs, Brigitte Begher‐Tibbe, Adrian Friebel, Kasimir Wansing, Ahmed Ghallab, Marie Rosselin, Noemie Boissier, Irene Vignon‐Clementel, Christian Hedberg, Fabian Geisler, Heribert Hofer, Peter Jansen, Stefan Hoehme, Dirk Drasdo, Jan G. Hengstler – 19 June 2020