Liver Transplant Survivorship

Jennifer C. Lai, Nneka N. Ufere, John C. Bucuvalas – 6 May 2020 – For both children and adults with end‐stage liver disease, liver transplantation represents a lifelong treatment, not a cure. The physical and psychological process of undergoing transplantation begins well before the surgery itself. Concerns regarding suffering and death from end‐stage liver disease are replaced by a lifelong need for multiple medications, ongoing monitoring of graft function, and heightened vigilance for complications related not only to the transplant itself but to longterm immunosuppression.

C24‐Ceramide Drives Gallbladder Cancer Progression Through Directly Targeting Phosphatidylinositol 5‐Phosphate 4‐Kinase Type‐2 Gamma to Facilitate Mammalian Target of Rapamycin Signaling Activation

Yonglong Zhang, Hui Wang, Tao Chen, Haolu Wang, Xiaowen Liang, Yuchen Zhang, Jinlin Duan, Shenjiao Qian, Ke Qiao, Lei Zhang, Yanfeng Liu, Jian Wang – 6 May 2020

Coronavirus Disease 2019 Hangover: A Rising Tide of Alcohol Use Disorder and Alcohol‐Associated Liver Disease

Ben L. Da, Gene Y. Im, Thomas D. Schiano – 5 May 2020 – The coronavirus disease 2019 (COVID‐19) pandemic has had a tremendous global impact since it began in November of 2019. However, there are concerns that the COVID‐19 pandemic will not affect all equally and that some populations will be particularly vulnerable. Relevant to liver disease, patients with alcohol use disorder (AUD) and alcohol‐associated liver disease (ALD) may be among the populations that are the most severely impacted.

Risk Factors and Center‐Level Variation in Hepatocellular Carcinoma Under‐Staging for Liver Transplantation

Nadim Mahmud, Maarouf A. Hoteit, David S. Goldberg – 4 May 2020 – Liver transplantation (LT) is curative for most patients with hepatocellular carcinoma (HCC). However, 10%‐15% of patients experience HCC recurrence. Patients who are reported as within Milan criteria by imaging are frequently found to be outside the criteria on explant. This under‐staging of HCC worsens post‐LT outcomes. However, risk factors for under‐staging have not been elucidated. Furthermore, it is not known if there is regional or center‐level variation in under‐staging.

Liver Transplantation for Acute‐on‐Chronic Liver Failure: Science or Fiction?

Jonel Trebicka, Vinay Sundaram, Richard Moreau, Rajiv Jalan, Vicente Arroyo – 4 May 2020 – Acute clinical deterioration of a patient with chronic liver disease remains a decisive time point both in terms of medical management and prognosis. This condition, also known as acute decompensation (AD), is an important event determining a crossroad in the trajectory of patients.

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