Osteopontin Takes Center Stage in Chronic Liver Disease

Zhuolun Song, Wei Chen, Dipti Athavale, Xiaodong Ge, Romain Desert, Sukanta Das, Hui Han, Natalia Nieto – 28 September 2020 – Osteopontin (OPN) was first identified in 1986. The prefix osteo‐ means bone; however, OPN is expressed in other tissues, including liver. The suffix ‐pontin means bridge and denotes the role of OPN as a link protein within the extracellular matrix. While OPN has well‐established physiological roles, multiple “omics” analyses suggest that it is also involved in chronic liver disease.

Hepatology Highlights

Alyson Kaplan, Russell Rosenblatt, Adam Buckholz, Sonal Kumar, Gopanandan Parthasarathy, Robert E. Schwartz, Petra Hirsova, Robert E. Schwartz, Joseph F. Pisa, Robert S. Brown, Nidhi Jalan‐Sakrikar, Robert E. Schwartz, Arun B. Jesudian, Nicholas W. Russo, Chaitanya Allamneni, Ravi S. Vora, Enis Kostallari, Robert E. Schwartz – 28 September 2020

Hepatology Highlights

Alyson Kaplan, Russell Rosenblatt, Adam Buckholz, Sonal Kumar, Gopanandan Parthasarathy, Robert E. Schwartz, Petra Hirsova, Robert E. Schwartz, Joseph F. Pisa, Robert S. Brown, Nidhi Jalan‐Sakrikar, Robert E. Schwartz, Arun B. Jesudian, Nicholas W. Russo, Chaitanya Allamneni, Ravi S. Vora, Enis Kostallari, Robert E. Schwartz – 28 September 2020

Interferon Type I Regulates Inflammasome Activation and High Mobility Group Box 1 Translocation in Hepatocytes During Ehrlichia‐Induced Acute Liver Injury

Muhamuda Kader, Abdeljabar El Andaloussi, Jennie Vorhaour, Kenichi Tamama, Natalia Nieto, Melanie J. Scott, Nahed Ismail – 27 September 2020 – Inflammasomes are an important innate immune host defense against intracellular microbial infection. Activation of inflammasomes by microbial or host ligands results in cleavage of caspase‐1 (canonical pathway) or caspase‐11 (noncanonical pathway), release of interleukin (IL)‐1β, IL‐18, high mobility group box 1 (HMGB1), and inflammatory cell death known as pyroptosis.

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