PORTICO: First Randomized Controlled Trial of Vasomodulator Therapy in Portopulmonary Hypertension
Sarah Raevens, Michael B. Fallon – 7 February 2020
Primary Alcohol‐Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene‐Expression Profiles
Xiao Liu, Sara Brin Rosenthal, Nairika Meshgin, Jacopo Baglieri, Sami G. Musallam, Karin Diggle, Kevin Lam, Raymond Wu, Stephanie Q. Pan, Yibu Chen, Ken Dorko, Sharon Presnell, Chris Benner, Mojgan Hosseini, Hidekazu Tsukamoto, David Brenner, Tatiana Kisseleva – 6 February 2020 – Alcoholic liver disease (ALD) is a leading cause of cirrhosis in the United States, which is characterized by extensive deposition of extracellular matrix proteins and formation of a fibrous scar. Hepatic stellate cells (HSCs) are the major source of collagen type 1 producing myofibroblasts in ALD fibrosis.
Letter to the Editor: Appraisal of Cardiac Ejection Fraction With Liver Disease Severity
Won Ho Kim, Seong‐Mi Yang, Kook Hyun Lee – 5 February 2020
Risk of Cirrhosis and Hepatocellular Cancer in Patients With NAFLD and Normal Liver Enzymes
Yamini Natarajan, Jennifer R. Kramer, Xian Yu, Liang Li, Aaron P. Thrift, Hashem B. El‐Serag, Fasiha Kanwal – 5 February 2020
Reply
Hye‐Mee Kwon, Gyu‐Sam Hwang – 5 February 2020
PDK4‐Deficiency Reprograms Intrahepatic Glucose and Lipid Metabolism to Facilitate Liver Regeneration in Mice
Yulan Zhao, Melanie Tran, Li Wang, Dong‐Ju Shin, Jianguo Wu – 5 February 2020 – Liver regeneration requires intrahepatic and extrahepatic metabolic reprogramming to meet the high hepatic bioenergy demand for liver cell repopulation. This study aims to elucidate how pyruvate dehydrogenase kinase 4 (PDK4), a critical regulator of glucose and lipid metabolism, coordinates metabolic regulation with efficient liver growth. We found that hepatic Pdk4 expression was elevated after two‐thirds partial hepatectomy (PHx).
Vasomodulators and Liver Transplantation for Portopulmonary Hypertension: Evidence From a Systematic Review and Meta‐Analysis
Rebecca Deroo, Eric Trépo, Tom Holvoet, Michel De Pauw, Anja Geerts, Xavier Verhelst, Isabelle Colle, Hans Van Vlierberghe, Michael B. Fallon, Sarah Raevens – 4 February 2020
Detection of Circulating Tumor Cells and Their Implications as a Biomarker for Diagnosis, Prognostication, and Therapeutic Monitoring in Hepatocellular Carcinoma
Joseph C. Ahn, Pai‐Chi Teng, Pin‐Jung Chen, Edwin Posadas, Hsian‐Rong Tseng, Shelly C. Lu, Ju Dong Yang – 4 February 2020 – Hepatocellular carcinoma (HCC) is among the leading causes of worldwide cancer‐related morbidity and mortality. Poor prognosis of HCC is attributed primarily to tumor presentation at an advanced stage when there is no effective treatment to achieve the long term survival of patients. Currently available tests such as alpha‐fetoprotein have limited accuracy as a diagnostic or prognostic biomarker for HCC.
Hepatocellular Carcinoma Demonstrates Heterogeneous Growth Patterns in a Multicenter Cohort of Patients With Cirrhosis
Nicole E. Rich, Binu V. John, Neehar D. Parikh, Ian Rowe, Neil Mehta, Gaurav Khatri, Smitha M. Thomas, Munazza Anis, Mishal Mendiratta‐Lala, Christopher Hernandez, Mobolaji Odewole, Latha T. Sundaram, Venkata R. Konjeti, Shishir Shetty, Tahir Shah, Hao Zhu, Adam C. Yopp, Yujin Hoshida, Francis Y. Yao, Jorge A. Marrero, Amit G. Singal – 4 February 2020
Detection of Circulating Tumor Cells and Their Implications as a Biomarker for Diagnosis, Prognostication, and Therapeutic Monitoring in Hepatocellular Carcinoma
Joseph C. Ahn, Pai‐Chi Teng, Pin‐Jung Chen, Edwin Posadas, Hsian‐Rong Tseng, Shelly C. Lu, Ju Dong Yang – 4 February 2020 – Hepatocellular carcinoma (HCC) is among the leading causes of worldwide cancer‐related morbidity and mortality. Poor prognosis of HCC is attributed primarily to tumor presentation at an advanced stage when there is no effective treatment to achieve the long term survival of patients. Currently available tests such as alpha‐fetoprotein have limited accuracy as a diagnostic or prognostic biomarker for HCC.