Assessment of Rapid Hepatic Glycogen Synthesis in Humans Using Dynamic 13C Magnetic Resonance Spectroscopy

Stefan Stender, Vlad G. Zaha, Craig R. Malloy, Jessica Sudderth, Ralph J. DeBerardinis, Jae Mo Park – 4 January 2020 – Carbon‐13 magnetic resonance spectroscopy (MRS) following oral intake of 13C‐labeled glucose is the gold standard for imaging glycogen metabolism in humans. However, the temporal resolution of previous studies has been >13 minutes. Here, we describe a high‐sensitivity 13C MRS method for imaging hepatic glycogen synthesis with a temporal resolution of 1 minute or less.

Recurrence After Curative Resection of Hepatitis B Virus–Related Hepatocellular Carcinoma: Diagnostic Algorithms on Gadoxetic Acid–Enhanced Magnetic Resonance Imaging

Wentao Wang, Chun Yang, Kai Zhu, Li Yang, Ying Ding, Rongkui Luo, Shuo Zhu, Caizhong Chen, Wei Sun, Mengsu Zeng, Sheng‐Xiang Rao – 4 January 2020 – Small recurrent hepatocellular carcinoma (HCC) can show atypical imaging patterns, and a specific diagnostic algorithm for HCC is lacking. This study aimed to better characterize postoperative recurrent HCCs <20 mm in size with gadoxetic acid–enhanced magnetic resonance imaging (MRI). We evaluated 373 newly developed nodules after hepatectomy in 204 HCC patients with chronic hepatitis B virus infection.

Outcomes of Liver Transplant for Adults With Wilson’s Disease

Alberto Ferrarese, Maria Cristina Morelli, Paola Carrai, Martina Milana, Mario Angelico, Giovanni Perricone, Luca Saverio Belli, Giuseppe Marrone, Antonio Grieco, Silvia Martini, Matteo Angelo Manini, Stefano Fagiuoli, Pierluigi Toniutto, Alfonso Galeota Lanza, Sherrie Bhoori, Salvatore Petta, Edoardo G. Giannini, Patrizia Burra – 4 January 2020 – Wilson’s disease (WD) is a rare genetic disorder with protean manifestations.

Woolly Monkey–HBV Infection in Squirrel Monkeys as a Surrogate Nonhuman Primate Model of HBV Infection

Christopher Y. Chen, Benjamin Y. Winer, Deborah Chavez, Bernadette Guerra, Kathleen M. Brasky, Stacey Eng, Eduardo Salas, Danny Tam, Joe H. Simmons, Christian R. Abee, William E. Delaney, Alexander Ploss, Robert E. Lanford, Christian Voitenleitner – 3 January 2020 – Development of curative therapies for chronic hepatitis B virus (HBV) infection will likely require new animal models. Here, we evaluate HBV infection in squirrel monkeys based on the high‐sequence homology of the HBV receptor, Na+/taurocholate co‐transporting peptide (NTCP), between humans and squirrel monkeys.

Targeting Liver Cancer Stem Cells Using Engineered Biological Nanoparticles for the Treatment of Hepatocellular Cancer

Kaori Ishiguro, Irene K. Yan, Laura Lewis‐Tuffin, Tushar Patel – 3 January 2020 – By exploiting their biological functions, the use of biological nanoparticles such as extracellular vesicles can provide an efficient and effective approach for hepatic delivery of RNA‐based therapeutics for the treatment of liver cancers such as hepatocellular cancer (HCC). Targeting liver cancer stem cells (LCSC) within HCC provide an untapped opportunity to improve outcomes by enhancing therapeutic responses.

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