Somatic Mutations in Liver Disease: Adaptation Without Carcinogenesis?
Irun Bhan, David T. Ting – 8 February 2020
Role of Autoimmunity in Patients Transplanted for Acute Liver Failure of Unknown Origin: A Clinical and Graft Biopsy Analysis
Ville Liukkonen, Arno Nordin, Johanna Arola, Martti Färkkilä, Fredrik Åberg – 8 February 2020 – The etiology and prognosis of acute liver failure (ALF) remains unknown in a significant proportion of cases. Signs of autoimmunity may be present, but no consistent pattern has been observed. We aimed to analyze if pretransplant immunological findings, human leukocyte antigen (HLA) haplotypes, and clinical features among patients with an unknown etiology differ from those of autoimmune or other known etiologies.
Chronic Kidney Disease in Cirrhosis: Emerging Complication With Negative Impact in the Liver Transplant Setting
Elsa Solà, Pere Ginès – 7 February 2020
Correction
7 February 2020
Hepatic Deficiency of Augmenter of Liver Regeneration Predisposes to Nonalcoholic Steatohepatitis and Fibrosis
Sudhir Kumar, Alok K. Verma, Richa Rani, Akanksha Sharma, Jiang Wang, Shimul A. Shah, Jaideep Behari, Rosa Salazar Gonzalez, Rohit Kohli, Chandrashekhar R. Gandhi – 7 February 2020
Liver Transplantation in Adults With Wilson’s Disease for the Neuropsychiatric Phenotype: Are We There Yet?
Mohamed A. Abdallah, Ashwani K. Singal – 7 February 2020
Liquid Biopsies for Hepatocellular Cancer and Their Potential in Clinical Practice
Gary P. Jeffrey, Louisa G. Gordon, Michelle M. Hill, Grant A. Ramm – 7 February 2020
PORTICO: First Randomized Controlled Trial of Vasomodulator Therapy in Portopulmonary Hypertension
Sarah Raevens, Michael B. Fallon – 7 February 2020
Primary Alcohol‐Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene‐Expression Profiles
Xiao Liu, Sara Brin Rosenthal, Nairika Meshgin, Jacopo Baglieri, Sami G. Musallam, Karin Diggle, Kevin Lam, Raymond Wu, Stephanie Q. Pan, Yibu Chen, Ken Dorko, Sharon Presnell, Chris Benner, Mojgan Hosseini, Hidekazu Tsukamoto, David Brenner, Tatiana Kisseleva – 6 February 2020 – Alcoholic liver disease (ALD) is a leading cause of cirrhosis in the United States, which is characterized by extensive deposition of extracellular matrix proteins and formation of a fibrous scar. Hepatic stellate cells (HSCs) are the major source of collagen type 1 producing myofibroblasts in ALD fibrosis.
PDK4‐Deficiency Reprograms Intrahepatic Glucose and Lipid Metabolism to Facilitate Liver Regeneration in Mice
Yulan Zhao, Melanie Tran, Li Wang, Dong‐Ju Shin, Jianguo Wu – 5 February 2020 – Liver regeneration requires intrahepatic and extrahepatic metabolic reprogramming to meet the high hepatic bioenergy demand for liver cell repopulation. This study aims to elucidate how pyruvate dehydrogenase kinase 4 (PDK4), a critical regulator of glucose and lipid metabolism, coordinates metabolic regulation with efficient liver growth. We found that hepatic Pdk4 expression was elevated after two‐thirds partial hepatectomy (PHx).