Hemostatic Alterations in Patients With Cirrhosis: From Primary Hemostasis to Fibrinolysis

Maxime G. Zermatten, Montserrat Fraga, Darius Moradpour, Debora Bertaggia Calderara, Alessandro Aliotta, Guido Stirnimann, Andrea De Gottardi, Lorenzo Alberio – 23 February 2020 – In the setting of liver cirrhosis (LC), profound hemostatic changes occur, which affect primary hemostasis, coagulation, and fibrinolysis. They involve prohemorrhagic and prothrombotic alterations at each of these steps. Patients with cirrhosis exhibit multifactorial thrombocytopenia and in vitro thrombocytopathy, counterbalanced by increased von Willebrand factor.

Hepatic Carbohydrate Response Element Binding Protein Activation Limits Nonalcoholic Fatty Liver Disease Development in a Mouse Model for Glycogen Storage Disease Type 1a

Yu Lei, Joanne A. Hoogerland, Vincent W. Bloks, Trijnie Bos, Aycha Bleeker, Henk Wolters, Justina C. Wolters, Brenda S. Hijmans, Theo H. Dijk, Rachel Thomas, Michel Weeghel, Gilles Mithieux, Riekelt H. Houtkooper, Alain Bruin, Fabienne Rajas, Folkert Kuipers, Maaike H. Oosterveer – 21 February 2020

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