Immunotherapy as a Downstaging Therapy for Liver Transplantation
Birgit Schwacha‐Eipper, Iulia Minciuna, Vanessa Banz, Jean François Dufour – 14 March 2020
Genetic Pathways in Nonalcoholic Fatty Liver Disease: Insights From Systems Biology
Silvia Sookoian, Carlos J. Pirola, Luca Valenti, Nicholas O. Davidson – 14 March 2020 – Nonalcoholic fatty liver disease (NAFLD) represents a burgeoning worldwide epidemic whose etiology reflects multiple interactions between environmental and genetic factors. Here, we review the major pathways and dominant genetic modifiers known to be relevant players in human NAFLD and which may determine key components of the heritability of distinctive disease traits including steatosis and fibrosis.
Genetic Pathways in Nonalcoholic Fatty Liver Disease: Insights From Systems Biology
Silvia Sookoian, Carlos J. Pirola, Luca Valenti, Nicholas O. Davidson – 14 March 2020 – Nonalcoholic fatty liver disease (NAFLD) represents a burgeoning worldwide epidemic whose etiology reflects multiple interactions between environmental and genetic factors. Here, we review the major pathways and dominant genetic modifiers known to be relevant players in human NAFLD and which may determine key components of the heritability of distinctive disease traits including steatosis and fibrosis.
Pregnancy in Liver Transplantation
Monika Sarkar, Deirdre Sawinski, Lisa Coscia, the American Society of Transplantation, Women’s Health Community of Practice – 14 March 2020
Reply
Josh Levitsky, Elisa Gordon – 14 March 2020
Integrated Treatment of Alcohol Use Disorder in Patients With Alcohol‐Associated Liver Disease: An Evolving Story
Michael R. Lucey, Ashwani K. Singal – 14 March 2020
Cell‐Free Virus‐Host Chimera DNA From Hepatitis B Virus Integration Sites as a Circulating Biomarker of Hepatocellular Cancer
Chiao‐Ling Li, Ming‐Chih Ho, You‐Yu Lin, Sheng‐Tai Tzeng, Yun‐Ju Chen, Hsin‐Yung Pai, Ya‐Chun Wang, Chi‐Ling Chen, Yu‐Hsin Lee, Ding‐Shinn Chen, Shiou‐Hwei Yeh, Pei‐Jer Chen – 14 March 2020
Hepatotoxicity From Immune Checkpoint Inhibitors: A Systematic Review and Management Recommendation
Thoetchai (Bee) Peeraphatdit, Jennifer Wang, Matthew A. Odenwald, Shaomin Hu, John Hart, Michael R. Charlton – 13 March 2020 – Immune checkpoint inhibitors (ICIs) are monoclonal antibodies targeting immune checkpoint molecules. ICIs are an immunotherapy for the treatment of many advanced malignancies. The advent of ICIs has been a major breakthrough in the field of oncology, a fact recognized by the 2018 Nobel Prize in Physiology or Medicine being awarded for the discovery.
Intestinal Microbiome‐Macrophage Crosstalk Contributes to Cholestatic Liver Disease by Promoting Intestinal Permeability in Mice
Anna Isaacs‐Ten, Marta Echeandia, Mar Moreno‐Gonzalez, Arlaine Brion, Andrew Goldson, Mark Philo, Angela M. Patterson, Aimee Parker, Mikel Galduroz, David Baker, Simon M. Rushbrook, Falk Hildebrand, Naiara Beraza – 13 March 2020
Drug‐Induced Liver Injury in GI Practice
Naemat Sandhu, Victor Navarro – 13 March 2020 – Although drug‐induced liver injury (DILI) is a rare clinical event, it carries significant morbidity and mortality, leaving it as the leading cause of acute liver failure in the United States. It is one of the most challenging diagnoses encountered by gastroenterologists. The development of various drug injury networks has played a vital role in expanding our knowledge regarding drug‐related and herbal and dietary supplement–related liver injury.