Inflammation‐Induced Long Intergenic Noncoding RNA (LINC00665) Increases Malignancy Through Activating the Double‐Stranded RNA–Activated Protein Kinase/Nuclear Factor Kappa B Pathway in Hepatocellular Carcinoma

Model for End‐Stage Liver Disease‐Lactate and Prediction of Inpatient Mortality in Patients With Chronic Liver Disease

Naveed Sarmast, Gerald O. Ogola, Maria Kouznetsova, Michael D. Leise, Ranjeeta Bahirwani, Rakhi Maiwall, Elliot Tapper, James Trotter, Jasmohan S. Bajaj, Leroy R. Thacker, Puneeta Tandon, Florence Wong, K. Rajender Reddy, Jacqueline G. O'Leary, Andrew Masica, Ariel M. Modrykamien, Patrick S. Kamath, Sumeet K. Asrani – 21 February 2020

LiverLearning®: 2020 Webinar: NLRB - How Is It Working So Far?

In the Spring of 2019, the National Liver Review Board was put into place. The purpose is to provide greater uniformity in assigning MELD exception scores. We have early data describing the initial outcomes of patients requesting MELD exception scores. There are also some early "lessons learned" in how to improve the process. Dissemination of this data would be helpful for practitioners requesting MELD scores for their patients. We will utilize a live webinar format that will be recorded for on-demand viewing on Liver Learning ® .James F. Trotter Dr.

Hepatocyte‐Specific Expression of Human Carboxylesterase 1 Attenuates Diet‐Induced Steatohepatitis and Hyperlipidemia in Mice

Yanyong Xu, Yingdong Zhu, Fathima Cassim Bawa, Shuwei Hu, Xiaoli Pan, Liya Yin, Yanqiao Zhang – 20 February 2020 – Rodents have at least five carboxylesterase 1 (Ces1) genes, whereas there is only one CES1 gene in humans, raising the question as to whether human CES1 and mouse Ces1 genes share the same functions. In this study, we investigate the role of human CES1 in the development of steatohepatitis or dyslipidemia in C57BL/6 mice. Hepatocyte‐specific expression of human CES1 prevented Western diet or alcohol‐induced steatohepatitis and hyperlipidemia.

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