Looking Into the Crystal Ball: Predicting the Future Challenges of Fibrotic NASH Treatment

Naim Alkhouri, Eric Lawitz, Mazen Noureddin – 28 March 2019 – Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease worldwide, and its aggressive form of nonalcoholic steatohepatitis (NASH) is becoming a leading cause for end‐stage liver disease and liver transplantation in the United States. In patients with NASH, the presence of advanced fibrosis is considered the most important prognostic factor in predicting liver‐related morbidity and mortality.

Hepatology Highlights

Kavitha M. Nair, Ravi S. Vora, Omar Y Mousa, Harmeet Malhi, Robert E. Schwartz, Joseph F. Pisa, Robert S. Brown, Hirsh D. Trivedi, Daryl T.Y. Lau, Nicole Shen, Akhil Shenoy, Jessica L. Maiers, Enis Kostallari, Petra Hirsova, Nicholas Russo, Tasha B. Kulai – 28 March 2019

The Effects of Liver Transplantation in Children With Niemann‐Pick Disease Type B

Yuan Liu, Yi Luo, Lei Xia, Bijun Qiu, Tao Zhou, Mingxuan Feng, Feng Xue, Xiaosong Chen, Longzhi Han, Jianjun Zhang, Qiang Xia – 26 March 2019 – We evaluated the effects of liver transplantation (LT) in children with Niemann‐Pick disease (NPD) type B. From October 2006 to October 2018, 7 of 1512 children who received LT at Ren Ji Hospital were diagnosed as NPD type B. The median age at diagnosis was 12 months (6‐14 months) with initial presentations of hepatosplenomegaly, growth retardation, repeated pneumonia, and diarrhea.

Clinical Implications of Donor Warm and Cold Ischemia Time in Donor After Circulatory Death Liver Transplantation

Flavio Paterno, James V. Guarrera, Koffi Wima, Tayyab Diwan, Madison C. Cuffy, Nadeem Anwar, E. Steve Woodle, Shimul Shah – 26 March 2019 – The use of donation after circulatory death (DCD) liver allografts has been constrained by limitations in the duration of donor warm ischemia time (DWIT), donor agonal time (DAT), and cold ischemia time (CIT). The purpose of this study is to assess the impact of longer DWIT, DAT, and CIT on graft survival and other outcomes in DCD liver transplants.

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