Yanyong Xu, Yingdong Zhu, Kavita Jadhav, Yuanyuan Li, Huihui Sun, Liya Yin, Takhar Kasumov, Xiaoli Chen, Yanqiao Zhang – 25 March 2019 – Hepatocytes are the major source of hepatic lipocalin‐2 (LCN2), which is up‐regulated in response to inflammation, injury, or metabolic stress. So far, the role of hepatocyte‐derived LCN2 in the development of nonalcoholic fatty liver disease (NAFLD) remains unknown.

Sehee Kim, Jeffrey Moore, Estella Alonso, Joseph Bednarek, Jorge A. Bezerra, Catherine Goodhue, Saul J. Karpen, Kathleen M. Loomes, John C. Magee, Vicky L. Ng, Averell H. Sherker, Caroline Smith, Cathie Spino, Veena Venkat, Kasper Wang, Ronald J. Sokol, Cara L. Mack, The Childhood Liver Disease Research Network – 25 March 2019 – Biliary atresia is a progressive fibroinflammatory cholangiopathy of infancy that is associated with activation of innate and adaptive immune responses targeting bile ducts.

Jeffrey M. Mah, Yvonne DeWit, Maya Djerboua, Alexandre Menard, Christopher M. Booth, Jennifer A. Flemming – 25 March 2019 – Transjugular intrahepatic portosystemic shunt (TIPS) is a procedure designed to treat portal hypertension. Hospital teaching status is an institutional factor found to be predictive of outcomes following several complex procedures; however, its impact on outcomes following TIPS is unknown. The aim of this study was to determine the association between hospital teaching status and long‐term survival in patients with cirrhosis receiving TIPS.

Johns Shaji Mathew, K.Y. Santosh Kumar, Krishnanunni Nair, Binoj Sivasankara Pillai Thankamony Amma, Lakshmi Krishnakumar, Dinesh Balakrishnan, Unnikrishnan Gopalakrishnan, Ramachandran Narayana Menon, Aleena Sunny, Puneet Dhar, Sudheer Othiyil Vayoth, Sudhindran Surendran – 25 March 2019 – Traditionally, deceased donor liver grafts receive dual perfusion (DP) through the portal vein and the hepatic artery (HA) either in situ or on the back table. HA perfusion is avoided in living donor liver grafts for fear of damage to the intima and consequent risk of hepatic artery thrombosis (HAT).

Jie Yang, Eric Trépo, Pierre Nahon, Qian Cao, Christophe Moreno, Eric Letouzé, Sandrine Imbeaud, Quentin Bayard, Thierry Gustot, Jacques Deviere, Paulette Bioulac‐Sage, Julien Calderaro, Nathalie Ganne‐Carrié, Alexis Laurent, Jean Frédéric Blanc, Erwan Guyot, Angela Sutton, Marianne Ziol, Jessica Zucman‐Rossi, Jean‐Charles Nault – 25 March 2019 – Recently, a loss of function variant (rs72613567) in 17‐beta‐hydroxysteroid dehydrogenase 13 (HSD17B13) has been identified as protective of nonalcoholic (NAFLD) and alcoholic liver disease (ALD).

Scott McHenry, Nicholas O. Davidson – 22 March 2019

Zhihao Wei, Jiankun Jia, Gang Heng, Huailong Xu, Juanjuan Shan, Guiqin Wang, Chungang Liu, Jianyu Xia, Haijun Zhou, Min Wu, Zhi Yang, Meiling Wang, Zhouxing Xiong, Hong Huang, Limei Liu, Cheng Qian – 22 March 2019 – Metabolic reprogramming endows cancer cells with the ability to adjust metabolic pathways to support heterogeneously biological processes. However, it is not known how the reprogrammed activities are implemented during differentiation of cancer stem cells (CSCs).

Daniel Azoulay, Chady Salloum, Rony Eshkenazi, Chaya Shwaartz, Eylon Lahat, Chetana Lim – 22 March 2019

Keiichi Fujiwara, Masayuki Nakano, Shin Yasui, Osamu Yokosuka, Naoya Kato – 22 March 2019

Mussarat N. Rahim, Rodrigo Liberal, Rosa Miquel, Nigel D. Heaton, Michael A. Heneghan – 22 March 2019 – Acute severe presentations of autoimmune hepatitis (AIH) represent a challenge for the transplant community. As a disease, it is poorly characterized, and there is a weak evidence base to guide diagnosis and treatment. Early identification of acute severe AIH is key because it determines the initiation of corticosteroids, which can be lifesaving. However, their use in this setting remains controversial.