Transjugular Intrahepatic Portosystemic Shunt: A Possible Risk Factor for Direct‐Acting Antiviral Treatment Failure in Patients With Hepatitis C?

Felix Piecha, Jan‐Michael Gänßler, Sabine Jordan, Can Ergen, Harald Ittrich, Johannes Kluwe, Sven Pischke, Ansgar W. Lohse, Julian Schulze zur Wiesch – 18 March 2019 – Direct‐acting antiviral (DAA) therapies have revolutionized the treatment of chronic hepatitis C virus infection, achieving sustained virological response (SVR) rates of >90% even in patients with advanced liver cirrhosis.

Vascular Remodeling of Visceral Arteries Following Interruption of the Splenic Artery During Liver Transplantation

Damiano Patrono, Eloisa Franchi, Fabio Guarasci, Germana Bartoli, Elisabetta Nada, Federica Rigo, Antonio Ottobrelli, Paolo Fonio, Mauro Salizzoni, Renato Romagnoli – 18 March 2019 – Splenic artery (SA) ligation can be performed during liver transplantation (LT) to avoid portal hyperperfusion, which is involved in the pathogenesis of both small‐for‐size and SA syndrome. The SA can also be used as an inflow for arterial reconstruction.

Underestimation of Liver Transplantation for Alcoholic Hepatitis in the National Transplant Database

Brian P. Lee, Gene Y. Im, John P. Rice, Ethan Weinberg, Christine Hsu, Oren K. Fix, George Therapondos, Hyosun Han, David W. Victor, Sheila Eswaran, Haripriya Maddur, Norah A. Terrault – 18 March 2019 – Alcohol‐associated liver disease (ALD) can be coded in United Network for Organ Sharing (UNOS) as either alcoholic cirrhosis or alcoholic hepatitis (AH), without having specific criteria to assign either diagnosis.

Medication‐Related Problems in Outpatients With Decompensated Cirrhosis: Opportunities for Harm Prevention

Kelly L. Hayward, Preya J. Patel, Patricia C. Valery, Leigh U. Horsfall, Catherine Y. Li, Penny L. Wright, Caroline J. Tallis, Katherine A. Stuart, Katharine M. Irvine, W. Neil Cottrell, Jennifer H. Martin, Elizabeth E. Powell – 18 March 2019 – People with decompensated cirrhosis are often prescribed a complex regimen of therapeutic and prophylactic medications. In other chronic diseases, polypharmacy increases the risk of medication misadventure and medication‐related problems (MRPs), with associated increased morbidity, mortality, and health care costs.

Spermidine Confers Liver Protection by Enhancing NRF2 Signaling Through a MAP1S‐Mediated Noncanonical Mechanism

Pengfei Liu, Montserrat Rojo Vega, Matthew Dodson, Fei Yue, Boyun Shi, Deyu Fang, Eli Chapman, Leyuan Liu, Donna D. Zhang – 15 March 2019 – Spermidine (SPD), a naturally occurring polyamine, has been recognized as a caloric restriction mimetic that confers health benefits, presumably by inducing autophagy. Recent studies have reported that oral administration of SPD protects against liver fibrosis and hepatocarcinogenesis through activation of microtubule associated protein 1S (MAP1S)–mediated autophagy.

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